Cumulative event numbers and rates during a 6-year follow-up of 32 patients
. | Years of HU therapy . | . | |
|---|---|---|---|
| Type of event . | 1 to 3 . | 4 to 6 . | |
| Hospitalizations, no. | |||
| No. | 82 | 142 | |
| Rate/100 patients-years | 85 | 148 | |
| Hospitalizations, d | |||
| No. | 446 | 855 | |
| Rate/100 patients-years | 465 | 890 | |
| Vaso-occlusive crisis, 2 or more than 2/y | |||
| No. | 15 | 22 | |
| Rate/100 patients-years | 16 | 23 | |
| Acute chest syndrome | |||
| No. | 0 | 3 | |
| Rate/100 patients-years | 0 | 3.1 | |
| Cerebrovascular event | |||
| No. | 0 | 1 | |
| Rate/100 patients-years | 0 | 1 | |
| Bone necrosis/dactylitis | |||
| No. | 1 | 0 | |
| Rate/100 patients-years | 1 | 0 | |
| Severe anemia | |||
| No. | 3 | 3 | |
| Rate/100 patients-years | 3.1 | 3.1 | |
| Mean hydroxyurea dose, mg/kg daily, no. | |||
| Less than 20 | 36 | 52 | |
| Between 20 to 25 | 47 | 26 | |
| More than 25 | 13 | 20 | |
. | Years of HU therapy . | . | |
|---|---|---|---|
| Type of event . | 1 to 3 . | 4 to 6 . | |
| Hospitalizations, no. | |||
| No. | 82 | 142 | |
| Rate/100 patients-years | 85 | 148 | |
| Hospitalizations, d | |||
| No. | 446 | 855 | |
| Rate/100 patients-years | 465 | 890 | |
| Vaso-occlusive crisis, 2 or more than 2/y | |||
| No. | 15 | 22 | |
| Rate/100 patients-years | 16 | 23 | |
| Acute chest syndrome | |||
| No. | 0 | 3 | |
| Rate/100 patients-years | 0 | 3.1 | |
| Cerebrovascular event | |||
| No. | 0 | 1 | |
| Rate/100 patients-years | 0 | 1 | |
| Bone necrosis/dactylitis | |||
| No. | 1 | 0 | |
| Rate/100 patients-years | 1 | 0 | |
| Severe anemia | |||
| No. | 3 | 3 | |
| Rate/100 patients-years | 3.1 | 3.1 | |
| Mean hydroxyurea dose, mg/kg daily, no. | |||
| Less than 20 | 36 | 52 | |
| Between 20 to 25 | 47 | 26 | |
| More than 25 | 13 | 20 | |