In vitro-determined etoposide-induced caspase 3 activation in relation to immunohistochemical apoptosis profile
Patient . | Mean etoposide-induced caspase 3 activity ratio (SD) . | Caspase 8 inhibition profile . | Caspase 9 inhibition profile . | Clinical complete remission . |
|---|---|---|---|---|
| 1 | 2.2 (0.02) | Yes | No | Yes |
| 2 | 1.8 (0.10) | Yes | No | Yes |
| 3 | 1.8 (0.03) | Yes | Yes | Yes |
| 4 | 1.7 (0.02) | Yes | No | Yes |
| 5 | 1.5 (0.03) | No | Yes | No |
| 6 | 1.4 (0.02) | No | Yes | No |
Patient . | Mean etoposide-induced caspase 3 activity ratio (SD) . | Caspase 8 inhibition profile . | Caspase 9 inhibition profile . | Clinical complete remission . |
|---|---|---|---|---|
| 1 | 2.2 (0.02) | Yes | No | Yes |
| 2 | 1.8 (0.10) | Yes | No | Yes |
| 3 | 1.8 (0.03) | Yes | Yes | Yes |
| 4 | 1.7 (0.02) | Yes | No | Yes |
| 5 | 1.5 (0.03) | No | Yes | No |
| 6 | 1.4 (0.02) | No | Yes | No |
A high ratio indicates relative strong sensitivity to etoposide-induced caspase 3 activation.