Patient clinical data
Xenograft . | Age at diagnosis, mo/sex . | ALL subtype . | Disease status at biopsy . | Length of CR1, mo . | Site of relapse . | Survival after first relapse, mo . | Current clinical status . | DEX IC50 . |
|---|---|---|---|---|---|---|---|---|
| ALL-2 | 65/F | c-ALL | Relapse 3 | 30 | BM/CNS | 46 | DOD | > 10 μM |
| ALL-3 | 154/M | Pre-B | Diagnosis | 38 | BM | 98* | CR2 | 4.7 nM |
| ALL-4 | 105/M | Ph+/B-ALL | Diagnosis | 10 | BM | 1 | DOD | > 10 μM |
| ALL-7 | 88/M | Biphen | Diagnosis | 7 | BM | 6 | DOD | > 10 μM |
| ALL-8 | 152/M | T-ALL | Relapse 1 | 17 | BM | 1 | DOD | 24.1 nM |
| ALL-10 | 48/M | c-ALL | Diagnosis | 62* | No relapse | NA | CR1 | > 10 μM |
| ALL-11 | 37/F | c-ALL | Diagnosis | 125* | No relapse | NA | CR1 | 6.5 nM |
| ALL-16 | 122/F | T-ALL | Diagnosis | 108* | No relapse | NA | CR1 | 1.2 nM |
| ALL-17 | 107/F | c-ALL | Diagnosis | 25 | CNS | 36* | CR2 | 20.1 nM |
| ALL-18 | 30/F | c-ALL | Relapse 1 | 43 | BM | 57* | CR2 | > 10 μM |
| ALL-19 | 194/M | c-ALL | Relapse 1 | 4 | BM | 7 | DOD | > 10 μM |
Xenograft . | Age at diagnosis, mo/sex . | ALL subtype . | Disease status at biopsy . | Length of CR1, mo . | Site of relapse . | Survival after first relapse, mo . | Current clinical status . | DEX IC50 . |
|---|---|---|---|---|---|---|---|---|
| ALL-2 | 65/F | c-ALL | Relapse 3 | 30 | BM/CNS | 46 | DOD | > 10 μM |
| ALL-3 | 154/M | Pre-B | Diagnosis | 38 | BM | 98* | CR2 | 4.7 nM |
| ALL-4 | 105/M | Ph+/B-ALL | Diagnosis | 10 | BM | 1 | DOD | > 10 μM |
| ALL-7 | 88/M | Biphen | Diagnosis | 7 | BM | 6 | DOD | > 10 μM |
| ALL-8 | 152/M | T-ALL | Relapse 1 | 17 | BM | 1 | DOD | 24.1 nM |
| ALL-10 | 48/M | c-ALL | Diagnosis | 62* | No relapse | NA | CR1 | > 10 μM |
| ALL-11 | 37/F | c-ALL | Diagnosis | 125* | No relapse | NA | CR1 | 6.5 nM |
| ALL-16 | 122/F | T-ALL | Diagnosis | 108* | No relapse | NA | CR1 | 1.2 nM |
| ALL-17 | 107/F | c-ALL | Diagnosis | 25 | CNS | 36* | CR2 | 20.1 nM |
| ALL-18 | 30/F | c-ALL | Relapse 1 | 43 | BM | 57* | CR2 | > 10 μM |
| ALL-19 | 194/M | c-ALL | Relapse 1 | 4 | BM | 7 | DOD | > 10 μM |
CR1 indicates alive in first complete remission; DEX, dexamethasone; c-ALL, common (CD10+) ALL; BM, bone marrow; CNS, central nervous system; DOD, dead of disease; CR2, alive in second complete remission; Ph+, Philadelphia chromosome-positive; Biphen, biphenotypic; NA, not applicable.
No event