Microarray analysis of enzymes involved in heme synthesis
. | Average signal intensity . | . | . | |
|---|---|---|---|---|
| Heme synthesis enzymes . | Wild-type . | Abcg2 -/- . | P . | |
| ALA synthase 1 | 799 | 675 | .02 | |
| ALA synthase 2 | 38 528 | 33 733 | .16 | |
| Aminolevulinate dehydratase | 7 880 | 6 602 | .38 | |
| Porphobilinogen deaminase | 17 175 | 15 458 | .5 | |
| Uroporphyrinogen III synthase | 4 078 | 4 416 | .37 | |
| Uroporphyrinogen decarboxylase | 8 216 | 6 404 | .03 | |
| Coproporphyrinogen oxidase | 6 045 | 9 388 | .00002* | |
| Protoporphyrinogen oxidase | 5 138 | 5 062 | .13 | |
| Ferrochelatase | 7 277 | 7 111 | .5 | |
. | Average signal intensity . | . | . | |
|---|---|---|---|---|
| Heme synthesis enzymes . | Wild-type . | Abcg2 -/- . | P . | |
| ALA synthase 1 | 799 | 675 | .02 | |
| ALA synthase 2 | 38 528 | 33 733 | .16 | |
| Aminolevulinate dehydratase | 7 880 | 6 602 | .38 | |
| Porphobilinogen deaminase | 17 175 | 15 458 | .5 | |
| Uroporphyrinogen III synthase | 4 078 | 4 416 | .37 | |
| Uroporphyrinogen decarboxylase | 8 216 | 6 404 | .03 | |
| Coproporphyrinogen oxidase | 6 045 | 9 388 | .00002* | |
| Protoporphyrinogen oxidase | 5 138 | 5 062 | .13 | |
| Ferrochelatase | 7 277 | 7 111 | .5 | |
Difference considered significant