Frequency of antibody response to recombinant H–Y proteins and H–X homologs in male patients who underwent transplantation and in healthy individuals
. | DBY . | UTY . | ZFY . | RPS4Y . | EIF1AY . | ≥1 H–Y . | ≥2 H–Y . | ≥1 H–X . |
|---|---|---|---|---|---|---|---|---|
| F → M HSCT, n = 75 (%) | 35 (46.6) | 18 (24) | 12 (16) | 4 (5.3) | 6 (8) | 39 (52) | 23 (30.6) | 13 (17.3) |
| M → M HSCT, n = 46, (%) | 0 | 0 | 4 (8.7) | 0 | 0 | 4 (8.7) | 0 | 6 (13) |
| Male donors, n = 64 (%) | 1 (1.6) | 0 | 0 | 1 (1.6) | 3 (4.7) | 5 (7.8) | 0 | 5 (7.8) |
| Female donors, n = 70 (%) | 11 (15.7) | 4 (5.7) | 3 (4.3) | 15 (21.4) | 9 (12.9) | 29 (41.4) | 8 (11.4) | 12 (17.1) |
. | DBY . | UTY . | ZFY . | RPS4Y . | EIF1AY . | ≥1 H–Y . | ≥2 H–Y . | ≥1 H–X . |
|---|---|---|---|---|---|---|---|---|
| F → M HSCT, n = 75 (%) | 35 (46.6) | 18 (24) | 12 (16) | 4 (5.3) | 6 (8) | 39 (52) | 23 (30.6) | 13 (17.3) |
| M → M HSCT, n = 46, (%) | 0 | 0 | 4 (8.7) | 0 | 0 | 4 (8.7) | 0 | 6 (13) |
| Male donors, n = 64 (%) | 1 (1.6) | 0 | 0 | 1 (1.6) | 3 (4.7) | 5 (7.8) | 0 | 5 (7.8) |
| Female donors, n = 70 (%) | 11 (15.7) | 4 (5.7) | 3 (4.3) | 15 (21.4) | 9 (12.9) | 29 (41.4) | 8 (11.4) | 12 (17.1) |
Statistical comparisons: DBY, UTY, ≥1 H–Y, ≥2 H–Y antibody frequency between male recipients with female donors (F → M HSCT) and either male recipients with male donors (M → M HSCT) or healthy males; P < .001, 2-sided Fisher exact test. DBY, UTY, ZFY, RPS4Y, and ≥2 H–Y antibody frequency between F → M HSCT and healthy females; P < .008, 2-sided Fisher exact test. DBY, RPS4Y, ≥1 H–Y, and ≥2 H–Y antibody frequency between female donors and male donors; P < .007, 2-sided Fisher exact test. Comparison of ≥1 H–Y with ≥1 H–X in F → M HSCT and healthy females; P < .0001, 2-sided McNemar test.