Table 1. Diagnostic criteria for ALPS... | American Society of Hematology

Table 1.

Diagnostic criteria for ALPS

Required
1. Chronic nonmalignant lymphoproliferation
2. Defective in vitro Fas-mediated lymphocyte apoptosis
3. At least 1% TCR α/β⁺, CD3⁺, CD4^-, CD8^- cells (DNTs) in peripheral blood or lymphoid tissue
Supporting
1. Autoimmune antibodies
2. Mutations in Fas gene, Fas ligand gene, or caspase 8 or 10 genes
Adapted with permission from Bleesing et al.¹⁶