Characteristics of centers performing HLA-identical sibling transplantation for patients with acute or chronic leukemia in the United States
Variables . | Center, no. (%) . | Patients, no. (%) . |
|---|---|---|
| No. of centers and patients | 88 | 1426 |
| Procedure volume | ||
| Total no. of transplants/y | ||
| Median (range) | 70 (11-> 400) | |
| 30 transplants or fewer/y | 14 (16) | 55 (4) |
| 31-60 transplants/y | 20 (23) | 227 (16) |
| 61-99 transplants/y | 31 (35) | 380 (27) |
| 100 or more transplants/y | 23 (26) | 764 (54) |
| Total no. of allogeneic transplants/y | ||
| Median (range) | 28 (1-> 200) | |
| 10 transplants or fewer/y | 18 (20) | 88 (6) |
| 11-20 transplants/y | 18 (20) | 161 (11) |
| 21-39 transplants/y | 24 (28) | 391 (27) |
| 40 transplants or more/y | 28 (32) | 786 (55) |
| Type of transplants performed | ||
| Related transplantation | 88 (100) | 1426 (100) |
| Unrelated transplantation | 62 (70) | 1165 (82) |
| Cord blood transplantation | 33 (38) | 574 (40) |
| Nonmyeloablative transplantation | 66 (75) | 1104 (77) |
| Outpatient transplantation | 48 (54) | 918 (64) |
| Years of center experience | ||
| Median (range) | 11 (1-33) | |
| Fewer than 8 y | 33 (38) | 259 (18) |
| 8-15 y | 30 (34) | 497 (35) |
| More than 15 y | 25 (28) | 670 (47) |
| Physician and health provider profile | ||
| Transplantation physicians/center, median (range) | 4 (1-19) | |
| Patient volume/y/MD | ||
| Median (range) | 1:20 (1:3-1:48) | |
| 20 or fewer patients/1 MD | 762 (53) | |
| More than 20 patients/1 MD | 664 (47) | |
| Academic appointments of physicians | ||
| None | 22 (25) | 225 (16) |
| Some | 9 (10) | 202 (14) |
| All | 57 (65) | 999 (70) |
| Physicians with peer reviewed grants | 51 (58) | 970 (68) |
| Physicians involved in research | 88 (100) | 1426 (100) |
| Involved in laboratory research | 60 (68) | 1134 (80) |
| Involved in clinical research | 88 (100) | 1426 (100) |
| Medical school affiliations | 68 (77) | 1143 (77) |
| Medical students and/or residents | 4 (6) | 57 (6) |
| Hematology-oncology and/or BMT fellows | 24 (35) | 390 (35) |
| All of the above | 40 (59) | 696 (59) |
| Nurse-patient ratio | ||
| 1:1/1:2 | 34 (39) | 480 (34) |
| 1:3 | 43 (49) | 606 (42) |
| 1:4 or greater | 11 (12) | 340 (24) |
| Transplant unit profile and resources | ||
| Hospital bed capacity | ||
| 199 or fewer | 8 (9) | 72 (5) |
| 200-299 | 10 (11) | 83 (6) |
| 300-499 | 21 (24) | 263 (18) |
| 500 or more | 49 (56) | 1008 (71) |
| Have devoted beds for BMT patients | 87 (99) | |
| Median (range) | 12 (1-70) | |
| Laminar air-flow rooms | ||
| None | 54 (61) | 799 (56) |
| Some | 18 (20) | 357 (25) |
| All | 16 (18) | 270 (19) |
| HEPA-filtered rooms | ||
| None | 5 (5) | 66 (5) |
| Some | 16 (18) | 313 (22) |
| All | 67 (76) | 1047 (73) |
| Percentage of patients enrolled in IRB-approved clinical protocols | ||
| 25% or less | 17 (19) | 177 (12) |
| 26%-50% | 21 (24) | 283 (20) |
| More than 50% | 50 (57) | 966 (68) |
| Full-time clinical research coordinators | ||
| None | 9 (10) | 72 (5) |
| 1 FTE | 30 (34) | 319 (22) |
| 2 FTE | 21 (24) | 283 (20) |
| 3 FTE or more | 28 (32) | 752 (53) |
| Units able to manage critically ill patients | 29 (33) | 559 (39) |
| Computerized order entry | 67 (76) | 1130 (79) |
| Electronic medical record-keeping | 51 (58) | 984 (69) |
| On-site stem cell processing laboratory | 84 (95) | 1410 (99) |
| Unit pharmacist present | 81 (92) | 1360 (95) |
| NCI-designated cancer center | 28 (32) | |
| Devoted psychologist/psychiatrist present | 54 (61) | 824 (58) |
| Routine psychological screening done | 75 (85) | 1217 (85) |
| Initial contact person | ||
| Nurses/nurse practitioners/physician assistants | 18 (20) | 344 (24) |
| Residents | 28 (32) | 466 (33) |
| Hematology/oncology or BMT fellows | 37 (42) | 558 (39) |
| Attendings | 5 (6) | 58 (4) |
| Systematic follow-up of patients | 76 (86) | 1234 (86) |
| Every 6 mo | 21 (24) | 422 (30) |
| Every year | 40 (45) | 608 (43) |
| Every other year | 15 (17) | 204 (14) |
| No systematic follow-up | 12 (14) | 192 (13) |
| Program has formal long-term follow-up program | 66 (75) | 1067 (75) |
| Has formal posttransplant immunization protocol | 69 (78) | 1104 (78) |
| Has formal protocol for screening posttransplant complications | 45 (51) | 733 (51) |
| Medical center characteristics | ||
| Geographic location | ||
| Urban | 70 (80) | 1164 (82) |
| Suburban/rural | 18 (20) | 262 (18) |
| Center for Excellence designation | 63 (72) | 1187 (83) |
| FACT accreditation | ||
| No | 13 (15) | 196 (13) |
| Yes, pending | 23 (26) | 290 (20) |
| Yes | 52 (59) | 940 (66) |
Variables . | Center, no. (%) . | Patients, no. (%) . |
|---|---|---|
| No. of centers and patients | 88 | 1426 |
| Procedure volume | ||
| Total no. of transplants/y | ||
| Median (range) | 70 (11-> 400) | |
| 30 transplants or fewer/y | 14 (16) | 55 (4) |
| 31-60 transplants/y | 20 (23) | 227 (16) |
| 61-99 transplants/y | 31 (35) | 380 (27) |
| 100 or more transplants/y | 23 (26) | 764 (54) |
| Total no. of allogeneic transplants/y | ||
| Median (range) | 28 (1-> 200) | |
| 10 transplants or fewer/y | 18 (20) | 88 (6) |
| 11-20 transplants/y | 18 (20) | 161 (11) |
| 21-39 transplants/y | 24 (28) | 391 (27) |
| 40 transplants or more/y | 28 (32) | 786 (55) |
| Type of transplants performed | ||
| Related transplantation | 88 (100) | 1426 (100) |
| Unrelated transplantation | 62 (70) | 1165 (82) |
| Cord blood transplantation | 33 (38) | 574 (40) |
| Nonmyeloablative transplantation | 66 (75) | 1104 (77) |
| Outpatient transplantation | 48 (54) | 918 (64) |
| Years of center experience | ||
| Median (range) | 11 (1-33) | |
| Fewer than 8 y | 33 (38) | 259 (18) |
| 8-15 y | 30 (34) | 497 (35) |
| More than 15 y | 25 (28) | 670 (47) |
| Physician and health provider profile | ||
| Transplantation physicians/center, median (range) | 4 (1-19) | |
| Patient volume/y/MD | ||
| Median (range) | 1:20 (1:3-1:48) | |
| 20 or fewer patients/1 MD | 762 (53) | |
| More than 20 patients/1 MD | 664 (47) | |
| Academic appointments of physicians | ||
| None | 22 (25) | 225 (16) |
| Some | 9 (10) | 202 (14) |
| All | 57 (65) | 999 (70) |
| Physicians with peer reviewed grants | 51 (58) | 970 (68) |
| Physicians involved in research | 88 (100) | 1426 (100) |
| Involved in laboratory research | 60 (68) | 1134 (80) |
| Involved in clinical research | 88 (100) | 1426 (100) |
| Medical school affiliations | 68 (77) | 1143 (77) |
| Medical students and/or residents | 4 (6) | 57 (6) |
| Hematology-oncology and/or BMT fellows | 24 (35) | 390 (35) |
| All of the above | 40 (59) | 696 (59) |
| Nurse-patient ratio | ||
| 1:1/1:2 | 34 (39) | 480 (34) |
| 1:3 | 43 (49) | 606 (42) |
| 1:4 or greater | 11 (12) | 340 (24) |
| Transplant unit profile and resources | ||
| Hospital bed capacity | ||
| 199 or fewer | 8 (9) | 72 (5) |
| 200-299 | 10 (11) | 83 (6) |
| 300-499 | 21 (24) | 263 (18) |
| 500 or more | 49 (56) | 1008 (71) |
| Have devoted beds for BMT patients | 87 (99) | |
| Median (range) | 12 (1-70) | |
| Laminar air-flow rooms | ||
| None | 54 (61) | 799 (56) |
| Some | 18 (20) | 357 (25) |
| All | 16 (18) | 270 (19) |
| HEPA-filtered rooms | ||
| None | 5 (5) | 66 (5) |
| Some | 16 (18) | 313 (22) |
| All | 67 (76) | 1047 (73) |
| Percentage of patients enrolled in IRB-approved clinical protocols | ||
| 25% or less | 17 (19) | 177 (12) |
| 26%-50% | 21 (24) | 283 (20) |
| More than 50% | 50 (57) | 966 (68) |
| Full-time clinical research coordinators | ||
| None | 9 (10) | 72 (5) |
| 1 FTE | 30 (34) | 319 (22) |
| 2 FTE | 21 (24) | 283 (20) |
| 3 FTE or more | 28 (32) | 752 (53) |
| Units able to manage critically ill patients | 29 (33) | 559 (39) |
| Computerized order entry | 67 (76) | 1130 (79) |
| Electronic medical record-keeping | 51 (58) | 984 (69) |
| On-site stem cell processing laboratory | 84 (95) | 1410 (99) |
| Unit pharmacist present | 81 (92) | 1360 (95) |
| NCI-designated cancer center | 28 (32) | |
| Devoted psychologist/psychiatrist present | 54 (61) | 824 (58) |
| Routine psychological screening done | 75 (85) | 1217 (85) |
| Initial contact person | ||
| Nurses/nurse practitioners/physician assistants | 18 (20) | 344 (24) |
| Residents | 28 (32) | 466 (33) |
| Hematology/oncology or BMT fellows | 37 (42) | 558 (39) |
| Attendings | 5 (6) | 58 (4) |
| Systematic follow-up of patients | 76 (86) | 1234 (86) |
| Every 6 mo | 21 (24) | 422 (30) |
| Every year | 40 (45) | 608 (43) |
| Every other year | 15 (17) | 204 (14) |
| No systematic follow-up | 12 (14) | 192 (13) |
| Program has formal long-term follow-up program | 66 (75) | 1067 (75) |
| Has formal posttransplant immunization protocol | 69 (78) | 1104 (78) |
| Has formal protocol for screening posttransplant complications | 45 (51) | 733 (51) |
| Medical center characteristics | ||
| Geographic location | ||
| Urban | 70 (80) | 1164 (82) |
| Suburban/rural | 18 (20) | 262 (18) |
| Center for Excellence designation | 63 (72) | 1187 (83) |
| FACT accreditation | ||
| No | 13 (15) | 196 (13) |
| Yes, pending | 23 (26) | 290 (20) |
| Yes | 52 (59) | 940 (66) |
BMT indicates bone marrow transplantation; IRB, institutional review board; FTE, full-time equivalent; FACT, Foundation for the Accreditation of Cellular Therapy.