Phage inserts selected after the third round of panning on U937/Tat cells and sequence alignment of the cognate gp120 regions from different viral strains (derived from Kuiken et al38)
Phage sequences | |
| Phage no. 1 | CTVECYFNCTPTC |
| Phage no. 2 | CPDRKKKKVVHVC |
| gp120 sequences | |
| Consensus_A | KNCSFNMTTELRDKKQKVY |
| Consensus_A1 | ------------------- |
| Consensus_A2 | ----Y-I-------T---- |
| Consensus_B | ------I---I---V--E- |
| Consensus_C | ------I------------ |
| Consensus_D | ------I--------KQ-H |
| Consensus_F1 | Q---------V----L--H |
| Consensus_F2 | ------I---IK---K-E- |
| Consensus_G | ------I---I----K-E- |
| Consensus_H | T-----V--VI---Q---H |
| Consensus_O | -K-E--V--V-K---E-KQ |
Phage sequences | |
| Phage no. 1 | CTVECYFNCTPTC |
| Phage no. 2 | CPDRKKKKVVHVC |
| gp120 sequences | |
| Consensus_A | KNCSFNMTTELRDKKQKVY |
| Consensus_A1 | ------------------- |
| Consensus_A2 | ----Y-I-------T---- |
| Consensus_B | ------I---I---V--E- |
| Consensus_C | ------I------------ |
| Consensus_D | ------I--------KQ-H |
| Consensus_F1 | Q---------V----L--H |
| Consensus_F2 | ------I---IK---K-E- |
| Consensus_G | ------I---I----K-E- |
| Consensus_H | T-----V--VI---Q---H |
| Consensus_O | -K-E--V--V-K---E-KQ |
Bold letters in phage sequences identify the regions with homology to gp120 protein.