Longitudinal linear regression analyses of patient- and platelet-related variables affecting posttransfusion platelet increments
. | 1 h after transfusion, n = 5778 . | . | . | 18 to 24 h after transfusion, n = 5103 . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | Platelet increment, × 109/L* . | 95% confidence interval, × 109/L . | P . | Platelet increment, × 109/L* . | 95% confidence interval, × 109/L . | P . | ||||
| Patient related | ||||||||||
| Increase platelet increment | ||||||||||
| Splenectomy | 24.8 | 15.3 to 34.3 | < .001 | 12.4 | 2.9 to 21.9 | .01 | ||||
| Age† | .1 | .05 to .15 | .001 | - | - | - | ||||
| Decrease platelet increment | ||||||||||
| Females with ≥ 2 pregnancies, or males | -8.9 | -6.5 to -11.3 | < .001 | -5.7 | -3.4 to -8.0 | < .001 | ||||
| Palpable spleen | -3.5 | -1.3 to -5.8 | .002 | -4.4 | -2.1 to -6.6 | < .001 | ||||
| Amphotericin | -2.7 | -1.9 to -3.6 | < .001 | -2.5 | -1.6 to -3.4 | < .001 | ||||
| Bleeding | -1.7 | -.6 to -2.8 | .003 | -3.1 | -2.0 to -4.3 | < .001 | ||||
| Fever | -1.6 | -.8 to -2.3 | < .001 | -2.0 | -1.2 to -2.7 | < .001 | ||||
| Infection | -1.5 | -.7 to -2.3 | < .001 | -1.8 | -.9 to -2.6 | < .001 | ||||
| Heparin | - | - | - | -3.8 | -1.7 to -5.9 | < .001 | ||||
| Weight‡ | -.19 | -.14 to -.24 | < .001 | -.15 | -.1 to -.2 | < .001 | ||||
| Height§ | -.14 | -.04 to -.23 | < .004 | - | - | - | ||||
| Transfusion sequence number¶ | -.2 | -.13 to -.27 | < .001 | -.21 | -.14 to -.28 | < .001 | ||||
| Platelet related | ||||||||||
| Increase platelet increment | ||||||||||
| ABO-compatible | 4.6 | 2.7 to 6.5 | < .001 | 6.3 | 4.3 to 8.2 | < .001 | ||||
| Stored ≤48 hours | 1.9 | 1.1 to 2.7 | < .001 | 2.0 | 1.2 to 2.8 | < .001 | ||||
| Decrease platelet increment | ||||||||||
| Gamma irradiated | -2.8 | -1.3 to -4.3 | < .001 | - | - | - | ||||
. | 1 h after transfusion, n = 5778 . | . | . | 18 to 24 h after transfusion, n = 5103 . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | Platelet increment, × 109/L* . | 95% confidence interval, × 109/L . | P . | Platelet increment, × 109/L* . | 95% confidence interval, × 109/L . | P . | ||||
| Patient related | ||||||||||
| Increase platelet increment | ||||||||||
| Splenectomy | 24.8 | 15.3 to 34.3 | < .001 | 12.4 | 2.9 to 21.9 | .01 | ||||
| Age† | .1 | .05 to .15 | .001 | - | - | - | ||||
| Decrease platelet increment | ||||||||||
| Females with ≥ 2 pregnancies, or males | -8.9 | -6.5 to -11.3 | < .001 | -5.7 | -3.4 to -8.0 | < .001 | ||||
| Palpable spleen | -3.5 | -1.3 to -5.8 | .002 | -4.4 | -2.1 to -6.6 | < .001 | ||||
| Amphotericin | -2.7 | -1.9 to -3.6 | < .001 | -2.5 | -1.6 to -3.4 | < .001 | ||||
| Bleeding | -1.7 | -.6 to -2.8 | .003 | -3.1 | -2.0 to -4.3 | < .001 | ||||
| Fever | -1.6 | -.8 to -2.3 | < .001 | -2.0 | -1.2 to -2.7 | < .001 | ||||
| Infection | -1.5 | -.7 to -2.3 | < .001 | -1.8 | -.9 to -2.6 | < .001 | ||||
| Heparin | - | - | - | -3.8 | -1.7 to -5.9 | < .001 | ||||
| Weight‡ | -.19 | -.14 to -.24 | < .001 | -.15 | -.1 to -.2 | < .001 | ||||
| Height§ | -.14 | -.04 to -.23 | < .004 | - | - | - | ||||
| Transfusion sequence number¶ | -.2 | -.13 to -.27 | < .001 | -.21 | -.14 to -.28 | < .001 | ||||
| Platelet related | ||||||||||
| Increase platelet increment | ||||||||||
| ABO-compatible | 4.6 | 2.7 to 6.5 | < .001 | 6.3 | 4.3 to 8.2 | < .001 | ||||
| Stored ≤48 hours | 1.9 | 1.1 to 2.7 | < .001 | 2.0 | 1.2 to 2.8 | < .001 | ||||
| Decrease platelet increment | ||||||||||
| Gamma irradiated | -2.8 | -1.3 to -4.3 | < .001 | - | - | - | ||||
Only variables with statistically significant effects are included in the table.
-indicates no significant effect.
Estimated change in platelet increment/μL at 1 hour or 18 to 24 hours after transfusion
An increase in age of 1 year increases platelet increment by 100/μL
An increase in weight of 1 kg decreases platelet increment by -190/μL or -150/μL at 1 hour or 18 to 24 hours after transfusion, respectively
An increase in height of 1 cm decreases platelet increment by -140/μL at 1 hour after transfusion
An increase of 1 in the transfusion sequence number decreases platelet increment by -200/μL or -210/μL at 1 hour and 18 to 24 hours after transfusion, respectively