Longitudinal linear regression analyses of patient- and platelet-related factors affecting platelet refractory rates
Variable . | Hazard ratio . | 95% confidence interval . | P . |
|---|---|---|---|
| Patient related | |||
| Increase platelet refractory rates | |||
| Lymphocytotoxic antibody-positive | 3.48 | 1.71-7.10 | .001 |
| Females with at least 2 pregnancies, or males | 2.78 | 0.18-0.72 | .004 |
| Heparin | 2.43 | 1.33-4.44 | .004 |
| Fever | 2.12 | 1.51-2.98 | < .001 |
| Bleeding | 2.00 | 1.22-3.17 | .006 |
| Transfusion sequence number | 1.15 | 1.09-1.21 | < .001 |
| Weight | 1.01 | 1.00-1.02 | .04 |
| Product related | |||
| Increase platelet refractory rates | |||
| Gamma irradiation | 1.45 | 1.01-2.07 | .04 |
| Decrease platelet refractory rates | |||
| Platelet dose | 0.53 | 0.44-0.62 | < .001 |
| F-AP | 0.58 | 0.38-0.89 | .01 |
Variable . | Hazard ratio . | 95% confidence interval . | P . |
|---|---|---|---|
| Patient related | |||
| Increase platelet refractory rates | |||
| Lymphocytotoxic antibody-positive | 3.48 | 1.71-7.10 | .001 |
| Females with at least 2 pregnancies, or males | 2.78 | 0.18-0.72 | .004 |
| Heparin | 2.43 | 1.33-4.44 | .004 |
| Fever | 2.12 | 1.51-2.98 | < .001 |
| Bleeding | 2.00 | 1.22-3.17 | .006 |
| Transfusion sequence number | 1.15 | 1.09-1.21 | < .001 |
| Weight | 1.01 | 1.00-1.02 | .04 |
| Product related | |||
| Increase platelet refractory rates | |||
| Gamma irradiation | 1.45 | 1.01-2.07 | .04 |
| Decrease platelet refractory rates | |||
| Platelet dose | 0.53 | 0.44-0.62 | < .001 |
| F-AP | 0.58 | 0.38-0.89 | .01 |
Platelet refractoriness was defined as 2 sequential transfusions with platelet increments of < 11.0 × 109 platelets/L at 1 hour after transfusion.