Isolation and characterization of aerolysin-resistant clones from normal bone marrow
Donor no./colony no. . | Colony type . | Exon . | Codon . | Positions and mutations . | Consequence . |
|---|---|---|---|---|---|
| 1/1 | CFU-GM/AE | 2 | 56 | 252T>C | Leu→Pro |
| 1/2 | CFU-GM/AE | 2 | 25-28 | 158-176 del 10bp | frame shift |
| 2/1 | CFU-GM/AE | 2 | 140 | 503insT | frame shift |
| 3/1 | CFU-GM/AE | 2 | 226 | 761insA | frame shift |
| 4/1 | CFU-GM/AE | 2 | 60 | 264T>C | Leu→Pro |
| 4/2 | CFU-GM/AE | 2 | 57, 58 | 256, 257delTC | frame shift |
| 4/3 | CFU-GM/AE | 2 | 238 | 799delA | frame shift |
| 4/4 | CFU-GM/AE | 5 | 337 | 1095delC | frame shift |
| 5/1 | CFU-GM/AE | 2 | 149 | 531delC | frame shift |
| 5/2 | CFU-GM/AE | 6 | 442 | 1410T>A | stop codon |
| 5/3 | CFU-GM/AE | 2 | 183 | 633G>A | Cys→Tyr |
| 6/1 | CFU-GM/AE | 2 | 145 | 518delA | frame shift |
| 7/1 | CFU-GM/AE | 2 | 57, 58 | 254-257delTCTC | frame shift |
| 8/1 | CFU-GM/AE | 5 | 380 | 1224delT | frame shift |
| 8/2 | CFU-GM/AE | 5 | 332 | 1079A>T | stop codon |
| 8/3 | CFU-GM/AE | 2 | 183 | 632T>C | Cys→Arg |
| 8/4 | CFU-GM/AE | 6 | 448-450 | 1427-1443delGATTCTA | frame shift |
| 8/5 | CFU-GM/AE | 5 | 380 | 1224insTA | frame shift |
| 9/1 | CFU-GM/AE | 2 | 155 | 549C>T | Ser→Phe |
| 9/2 | CFU-GM/AE | 2 | 155 | 549C>T | Ser→Phe |
| 9/3 | CFU-GM/AE | 2 | 155 | 549C>T | Ser→Phe |
| 9/4 | CFU-GM/AE | 2 | 168, 169 | 588-591delACAA | frame shift |
| 9/5 | CFU-GM/AE | 2 | 168, 169 | 588-591delACAA | frame shift |
| 9/6 | CFU-GM/AE | 6 | 421 | 1347delG | frame shift |
| 9/7 | CFU-GM/AE | 4 | 294 | 965delG | frame shift |
Donor no./colony no. . | Colony type . | Exon . | Codon . | Positions and mutations . | Consequence . |
|---|---|---|---|---|---|
| 1/1 | CFU-GM/AE | 2 | 56 | 252T>C | Leu→Pro |
| 1/2 | CFU-GM/AE | 2 | 25-28 | 158-176 del 10bp | frame shift |
| 2/1 | CFU-GM/AE | 2 | 140 | 503insT | frame shift |
| 3/1 | CFU-GM/AE | 2 | 226 | 761insA | frame shift |
| 4/1 | CFU-GM/AE | 2 | 60 | 264T>C | Leu→Pro |
| 4/2 | CFU-GM/AE | 2 | 57, 58 | 256, 257delTC | frame shift |
| 4/3 | CFU-GM/AE | 2 | 238 | 799delA | frame shift |
| 4/4 | CFU-GM/AE | 5 | 337 | 1095delC | frame shift |
| 5/1 | CFU-GM/AE | 2 | 149 | 531delC | frame shift |
| 5/2 | CFU-GM/AE | 6 | 442 | 1410T>A | stop codon |
| 5/3 | CFU-GM/AE | 2 | 183 | 633G>A | Cys→Tyr |
| 6/1 | CFU-GM/AE | 2 | 145 | 518delA | frame shift |
| 7/1 | CFU-GM/AE | 2 | 57, 58 | 254-257delTCTC | frame shift |
| 8/1 | CFU-GM/AE | 5 | 380 | 1224delT | frame shift |
| 8/2 | CFU-GM/AE | 5 | 332 | 1079A>T | stop codon |
| 8/3 | CFU-GM/AE | 2 | 183 | 632T>C | Cys→Arg |
| 8/4 | CFU-GM/AE | 6 | 448-450 | 1427-1443delGATTCTA | frame shift |
| 8/5 | CFU-GM/AE | 5 | 380 | 1224insTA | frame shift |
| 9/1 | CFU-GM/AE | 2 | 155 | 549C>T | Ser→Phe |
| 9/2 | CFU-GM/AE | 2 | 155 | 549C>T | Ser→Phe |
| 9/3 | CFU-GM/AE | 2 | 155 | 549C>T | Ser→Phe |
| 9/4 | CFU-GM/AE | 2 | 168, 169 | 588-591delACAA | frame shift |
| 9/5 | CFU-GM/AE | 2 | 168, 169 | 588-591delACAA | frame shift |
| 9/6 | CFU-GM/AE | 6 | 421 | 1347delG | frame shift |
| 9/7 | CFU-GM/AE | 4 | 294 | 965delG | frame shift |