Poisson distribution of mutational frequency
. | . | Chance of n or more PIG-A mutations . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Population of HSCs . | Mutational frequency . | n = 1 . | n = 2 . | n = 3 . | n = 5 . | n = 10 . | ||||
| 1 000 | 15 × 10-6 | 0.02 | 1.11 × 10-4 | 5.56 × 10-7 | 6.25 × 10-12 | 0 | ||||
| 1 000 | 60 × 10-6 | 0.06 | 1.73 × 10-3 | 3.44 × 10-5 | 6.16 × 10-9 | 0 | ||||
| 10 000 | 15 × 10-6 | 0.14 | 0.01 | 5.03 × 10-4 | 5.59 × 10-7 | 1.33 × 10-15 | ||||
| 10 000 | 60 × 10-6 | 0.45 | 0.08 | 0.02 | 3.94 × 10-4 | 9.67 × 10-10 | ||||
. | . | Chance of n or more PIG-A mutations . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Population of HSCs . | Mutational frequency . | n = 1 . | n = 2 . | n = 3 . | n = 5 . | n = 10 . | ||||
| 1 000 | 15 × 10-6 | 0.02 | 1.11 × 10-4 | 5.56 × 10-7 | 6.25 × 10-12 | 0 | ||||
| 1 000 | 60 × 10-6 | 0.06 | 1.73 × 10-3 | 3.44 × 10-5 | 6.16 × 10-9 | 0 | ||||
| 10 000 | 15 × 10-6 | 0.14 | 0.01 | 5.03 × 10-4 | 5.59 × 10-7 | 1.33 × 10-15 | ||||
| 10 000 | 60 × 10-6 | 0.45 | 0.08 | 0.02 | 3.94 × 10-4 | 9.67 × 10-10 | ||||
Table shows chance of n or more clones (n equals 1, 2, 3, 5, or 10, as indicated) in the population size (no. of active HSCs) with the given frequency (Mf), according to a Poisson distribution.