Comparison among ATM/TP53 gene status, drug response, and clinical stage in 26 B-CLL tumors
B-CLL tumor . | ATM and TP53 status . | VH gene status . | Disease stage . | Response to fludarabine in vitro . |
|---|---|---|---|---|
| 9206TR | ATM wild type | N | A | Resistant* |
| 9348AA | ATM wild type | M | A | Resistant |
| 8375AE | ATM mutant | UM | C | Resistant |
| 9439MS | ATM mutant | UM | B | Resistant |
| 8944MK | ATM mutant | UM | B | Resistant |
| 9292TT | ATM mutant | UM | C | Resistant |
| 6692MM | TP53 mutant | M | C | Sensitive |
| 6032RB | TP53 mutant | UM | C | Sensitive |
| 5266BP | TP53 mutant | UM | C | Sensitive |
| 9283PA | TP53 mutant | M | A | Sensitive |
| MB | ATM mutant | UM | C | Sensitive |
| SS | ATM wild type | N | B | Sensitive |
| 8992JF | ATM wild type | M | A | Sensitive |
| 8998GN | ATM wild type | M | B | Sensitive |
| 9375JM | ATM wild type | M | B | Sensitive |
| 8815DH | ATM wild type | M | C | Sensitive |
| 9277BL | ATM mutant | UM | C | Sensitive |
| 9355EM | ATM wild type | M | C | Sensitive |
| 9264JM | ATM mutant | M | A | Sensitive |
| 9447TQ | ATM wild type | UM | A | Sensitive |
| 8955ML | ATM wild type | UM | A | Sensitive |
| 28SW | ATM wild type | UM | B | Sensitive |
| 102JK | ATM wild type | M | A | Sensitive |
| 111AL | ATM wild type | N | A | Sensitive |
| 119BS | ATM wild type | M | C | Sensitive |
| 9236PA | ATM wild type | UM | B | Sensitive |
B-CLL tumor . | ATM and TP53 status . | VH gene status . | Disease stage . | Response to fludarabine in vitro . |
|---|---|---|---|---|
| 9206TR | ATM wild type | N | A | Resistant* |
| 9348AA | ATM wild type | M | A | Resistant |
| 8375AE | ATM mutant | UM | C | Resistant |
| 9439MS | ATM mutant | UM | B | Resistant |
| 8944MK | ATM mutant | UM | B | Resistant |
| 9292TT | ATM mutant | UM | C | Resistant |
| 6692MM | TP53 mutant | M | C | Sensitive |
| 6032RB | TP53 mutant | UM | C | Sensitive |
| 5266BP | TP53 mutant | UM | C | Sensitive |
| 9283PA | TP53 mutant | M | A | Sensitive |
| MB | ATM mutant | UM | C | Sensitive |
| SS | ATM wild type | N | B | Sensitive |
| 8992JF | ATM wild type | M | A | Sensitive |
| 8998GN | ATM wild type | M | B | Sensitive |
| 9375JM | ATM wild type | M | B | Sensitive |
| 8815DH | ATM wild type | M | C | Sensitive |
| 9277BL | ATM mutant | UM | C | Sensitive |
| 9355EM | ATM wild type | M | C | Sensitive |
| 9264JM | ATM mutant | M | A | Sensitive |
| 9447TQ | ATM wild type | UM | A | Sensitive |
| 8955ML | ATM wild type | UM | A | Sensitive |
| 28SW | ATM wild type | UM | B | Sensitive |
| 102JK | ATM wild type | M | A | Sensitive |
| 111AL | ATM wild type | N | A | Sensitive |
| 119BS | ATM wild type | M | C | Sensitive |
| 9236PA | ATM wild type | UM | B | Sensitive |
The response to CYC20 in vitro was sensitive in all tumors.
N indicates not known; M, mutated; and UM, unmutated.
Less than 40% of cells apoptotic at 72 hours