Predictive factors of clinical and molecular CR after rituximab
. | Univariate . | . | Multivariate by logistic analysis . | . | ||
|---|---|---|---|---|---|---|
| Factors . | No. CR/no. total (%) . | P, χ2 . | OR (95% CI) . | P . | ||
| Sex | .46 | 0.09 (0.01-0.69) | .02 | |||
| Male | 11/28 (39) | |||||
| Female | 10/15 (67) | |||||
| Age | .95 | 0.22 (0.22-2.58) | .23 | |||
| 60 y or younger | 18/37 (49) | |||||
| Older than 60 y | 3/6 (50) | |||||
| LDH* | .19 | 0.09 (0.003-2.11) | .13 | |||
| Yes | 1/5 (20) | |||||
| No | 18/37 (51) | |||||
| Bulky disease | .34 | 0.37 (0.06-2.37) | .30 | |||
| Yes | 4/11 (36) | |||||
| No | 17/32 (53) | |||||
| BM infiltration (histology) | .52 | 0.32 (0.08-3.30) | .49 | |||
| Yes | 15/32 (47) | |||||
| No | 6/11 (55) | |||||
| RQ-PCR on BM at diagnosis† | .15 | 3.23 (1.01-10.31) | .05 | |||
| High | 4/14 (29) | |||||
| Intermediate | 11/20 (55) | |||||
| Low | 6/9 (67) | |||||
. | Univariate . | . | Multivariate by logistic analysis . | . | ||
|---|---|---|---|---|---|---|
| Factors . | No. CR/no. total (%) . | P, χ2 . | OR (95% CI) . | P . | ||
| Sex | .46 | 0.09 (0.01-0.69) | .02 | |||
| Male | 11/28 (39) | |||||
| Female | 10/15 (67) | |||||
| Age | .95 | 0.22 (0.22-2.58) | .23 | |||
| 60 y or younger | 18/37 (49) | |||||
| Older than 60 y | 3/6 (50) | |||||
| LDH* | .19 | 0.09 (0.003-2.11) | .13 | |||
| Yes | 1/5 (20) | |||||
| No | 18/37 (51) | |||||
| Bulky disease | .34 | 0.37 (0.06-2.37) | .30 | |||
| Yes | 4/11 (36) | |||||
| No | 17/32 (53) | |||||
| BM infiltration (histology) | .52 | 0.32 (0.08-3.30) | .49 | |||
| Yes | 15/32 (47) | |||||
| No | 6/11 (55) | |||||
| RQ-PCR on BM at diagnosis† | .15 | 3.23 (1.01-10.31) | .05 | |||
| High | 4/14 (29) | |||||
| Intermediate | 11/20 (55) | |||||
| Low | 6/9 (67) | |||||
Of 43 patients eligible for analysis, observations were made in 42.
The LDH value was not available at diagnosis in one patient
The amount of BCL2/IgH+ cells in the BM was defined as being high, when more than one positive cell was detected among 100 normal cells; intermediate, when 1 positive cell was detected among 100 to 1000 normal cells; or low, when 1 positive cell in was detected among 1000 to 100 000 normal cells