Hematopoietic progenitor cell production in gp130Y757F/Y757F mice
Parameter . | +/+, mean ± SD* . | F/F, mean ± SD* . |
|---|---|---|
| Bone marrow | ||
| Total† | 54 ± 16 | 81 ± 20§ |
| Granulocyte | 16 ± 2 | 27 ± 2§ |
| Granulocyte/macrophage | 10 ± 3 | 15 ± 2§ |
| Macrophage | 17 ± 3 | 20 ± 4 |
| Eosinophil | 2 ± 1 | 11 ± 3§ |
| Blast | 5 ± 1 | 6 ± 2 |
| Megakaryocyte | 4 ± 2 | 2 ± 1 |
| CFU-Sd12‡§ | 4.5 ± 1.1 | 9.1 ± 1.6§ |
| Spleen | ||
| Total† | 5 ± 3 | 36 ± 28§ |
| Granulocyte | 1 ± 1 | 7 ± 1§ |
| Granulocyte/macrophage | 1 ± 0 | 8 ± 4§ |
| Macrophage | 1 ± 1 | 7 ± 2§ |
| Blast | 1 ± 0 | 6 ± 4§ |
| Megakaryocyte | 2 ± 1 | 8 ± 6 |
| CFU-Sd12‡§ | 1.2 ± 0.2 | 5.7 ± 1.2§ |
Parameter . | +/+, mean ± SD* . | F/F, mean ± SD* . |
|---|---|---|
| Bone marrow | ||
| Total† | 54 ± 16 | 81 ± 20§ |
| Granulocyte | 16 ± 2 | 27 ± 2§ |
| Granulocyte/macrophage | 10 ± 3 | 15 ± 2§ |
| Macrophage | 17 ± 3 | 20 ± 4 |
| Eosinophil | 2 ± 1 | 11 ± 3§ |
| Blast | 5 ± 1 | 6 ± 2 |
| Megakaryocyte | 4 ± 2 | 2 ± 1 |
| CFU-Sd12‡§ | 4.5 ± 1.1 | 9.1 ± 1.6§ |
| Spleen | ||
| Total† | 5 ± 3 | 36 ± 28§ |
| Granulocyte | 1 ± 1 | 7 ± 1§ |
| Granulocyte/macrophage | 1 ± 0 | 8 ± 4§ |
| Macrophage | 1 ± 1 | 7 ± 2§ |
| Blast | 1 ± 0 | 6 ± 4§ |
| Megakaryocyte | 2 ± 1 | 8 ± 6 |
| CFU-Sd12‡§ | 1.2 ± 0.2 | 5.7 ± 1.2§ |
Values represent the mean ± SD from 5 mice for each genotype
Number of colonies in semisolid agar cultures containing 2.5 ± 104 bone marrow cells or 2.5 ± 105 spleen cells. Cells were stimulated with IL-3 and SCF
Number of colonies on spleens from irradiated wild-type mice injected with 7.5 × 104 bone marrow cells or 3.75 × 105 spleen cells from gp130+/+ or gp130Y757F/Y757F mice
P < .05 versus data from gp130+/+ mice. No other statistically significant differences were observed between genotypes