IC50 values of paclitaxel or docetaxel in the presence of R115777 in MM cell lines
. | RPMI8226/S . | . | U266 . | . | H929 . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| R115777, nM . | P . | D . | P . | D . | P . | D . | |||
| 0 | 2.5 | 0.6 | 5.5 | 8.0 | 3.0 | 8.0 | |||
| 10 | 1.2 | 0.35 | 4.0 | — | 2.8 | — | |||
| 30 | 1.0 | 0.25 | 4.0 | 8.0 | 2.5 | 8.0 | |||
| 100 | 0.8 | 0.2 | 3.0 | 5.0 | 2.0 | 6.0 | |||
. | RPMI8226/S . | . | U266 . | . | H929 . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| R115777, nM . | P . | D . | P . | D . | P . | D . | |||
| 0 | 2.5 | 0.6 | 5.5 | 8.0 | 3.0 | 8.0 | |||
| 10 | 1.2 | 0.35 | 4.0 | — | 2.8 | — | |||
| 30 | 1.0 | 0.25 | 4.0 | 8.0 | 2.5 | 8.0 | |||
| 100 | 0.8 | 0.2 | 3.0 | 5.0 | 2.0 | 6.0 | |||
Data obtained with MTT assays with 72-hour incubation of drugs. Taxane concentrations are labeled in nM.
P indicates paclitaxel; D, docetaxel; —, not determined.