Proposed functions for Hoxa9 and Meis1 in normal HSP and LCP, based on the function of Hoxa9 in immortalized SCF-dependent myeloid progenitor cell lines, and of Meis1 in the Meis1/Hoxa9-immortalized myeloid-lymphoid progenitors that express unique ST-HSC genes
Function in SCF-dependent progenitor cell lines . | Proposed function in HSP and LCP in vivo . |
|---|---|
| Hoxa9 | |
| Maintains genetic program specifying self-renewal | Positively regulates self-renewal |
| Meis1 | |
| Stimulates proliferation | Positively regulates proliferation |
| Prevents differentiation by G-CSF | Suppresses premature differentiation by lineage-specific cytokines |
| Induces expression of FLT3, IL-7R, CD27 | Positively regulates proliferation/differentiation response by controlling the abundance of receptors for cytokines |
| Induces expression of CD34, Itgβ7, C1qR1 | Regulates homing and migration by controlling the levels of proteins that bind sugars and extracellular matrix proteins |
Function in SCF-dependent progenitor cell lines . | Proposed function in HSP and LCP in vivo . |
|---|---|
| Hoxa9 | |
| Maintains genetic program specifying self-renewal | Positively regulates self-renewal |
| Meis1 | |
| Stimulates proliferation | Positively regulates proliferation |
| Prevents differentiation by G-CSF | Suppresses premature differentiation by lineage-specific cytokines |
| Induces expression of FLT3, IL-7R, CD27 | Positively regulates proliferation/differentiation response by controlling the abundance of receptors for cytokines |
| Induces expression of CD34, Itgβ7, C1qR1 | Regulates homing and migration by controlling the levels of proteins that bind sugars and extracellular matrix proteins |