Clinical characteristics of case patients at time of admission to HDU by α+ thalassemia genotype
. | No. (%)* . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| Characteristic . | All genotypes . | αα/αα . | -α/αα . | -α/-α . | |||
| Prostration† | 275 (42) | 106 (40.2) | 135 (43.8) | 34 (41.0) | |||
| Coma† | 285 (44) | 119 (45.1) | 133 (43.2) | 33 (39.8) | |||
| Deep breathing† | 239 (37) | 95 (36.0) | 111 (36.0) | 33 (39.8) | |||
| Coma and deep breathing | 94 (14) | 38 (14.4) | 47 (15.3) | 9 (10.8) | |||
| Symptomatic SMA‡ | 153 (23) | 68 (25.8) | 69 (22.4) | 15 (18.1) | |||
| Metabolic acidosis§ | 422/598 (71) | 175/241 (72.6) | 190/283 (67.1) | 57/54 (77.0) | |||
| Hypoglycemia∥ | 100/645 (16) | 40/258 (15.5) | 43/305 (14.1) | 17/82 (20.7) | |||
| Fatal outcome¶ | 72 (11) | 33 (12.5) | 32 (10.4) | 7 (8.4) | |||
. | No. (%)* . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| Characteristic . | All genotypes . | αα/αα . | -α/αα . | -α/-α . | |||
| Prostration† | 275 (42) | 106 (40.2) | 135 (43.8) | 34 (41.0) | |||
| Coma† | 285 (44) | 119 (45.1) | 133 (43.2) | 33 (39.8) | |||
| Deep breathing† | 239 (37) | 95 (36.0) | 111 (36.0) | 33 (39.8) | |||
| Coma and deep breathing | 94 (14) | 38 (14.4) | 47 (15.3) | 9 (10.8) | |||
| Symptomatic SMA‡ | 153 (23) | 68 (25.8) | 69 (22.4) | 15 (18.1) | |||
| Metabolic acidosis§ | 422/598 (71) | 175/241 (72.6) | 190/283 (67.1) | 57/54 (77.0) | |||
| Hypoglycemia∥ | 100/645 (16) | 40/258 (15.5) | 43/305 (14.1) | 17/82 (20.7) | |||
| Fatal outcome¶ | 72 (11) | 33 (12.5) | 32 (10.4) | 7 (8.4) | |||
Number and percentage of genotypic group manifesting clinical characteristic. N = 655 case patients in all categories except metabolic acidosis and hypoglycemia, for which denominators are shown
Defined as previously described8
Hemoglobin less than 5 g/dL, falciparum malaria, acidosis, and deep breathing
Base deficit greater than 8 mM
Blood glucose less than 2.5 mM
Deaths in hospital after admission