Laboratory findings in case patients by α+ thalassemia
. | Genotype frequencies, mean (SE) . | . | . | ||
|---|---|---|---|---|---|
. | Normal α-globin genotype αα/αα . | Heterozygous α+ thalassemia -α/αα . | Homozygous α+ thalassemia -α/-α . | ||
| Hemoglobin, g/dL | 6.95 (0.16) | 7.08 (0.16) | 7.12 (0.26) | ||
| MCV, fL | 75.8 (0.6) | 72.6 (0.5) | 68.2 (1.1) | ||
| Platelets, ×106/L | 162 (10) | 159 (9) | 187 (20) | ||
| Sodium, mM | 134 (0) | 134 (0) | 135 (1) | ||
| Potassium, mM | 4.4 (0.1) | 4.3 (0.1) | 4.3 (0.1) | ||
| Creatinine, μM | 72.2 (2.7) | 66.1 (2.3) | 71.9 (4.8) | ||
| Glucose, mM* | 5.8 (0.2) | 5.6 (0.2) | 5.0 (0.3) | ||
| pH* | 7.28 (0.01) | 7.28 (0.01) | 7.27 (0.01) | ||
| Bicarbonate, mM* | 13.13 (0.33) | 13.83 (0.29) | 12.85 (0.55) | ||
| Base deficit, mM* | 12.06 (0.43) | 11.24 (0.35) | 12.22 (0.67) | ||
| Parasitemia, log10 value/μL | 4.8 (4.5-5.0) | 4.6 (4.4-4.7) | 4.6 (4.5-4.8) | ||
. | Genotype frequencies, mean (SE) . | . | . | ||
|---|---|---|---|---|---|
. | Normal α-globin genotype αα/αα . | Heterozygous α+ thalassemia -α/αα . | Homozygous α+ thalassemia -α/-α . | ||
| Hemoglobin, g/dL | 6.95 (0.16) | 7.08 (0.16) | 7.12 (0.26) | ||
| MCV, fL | 75.8 (0.6) | 72.6 (0.5) | 68.2 (1.1) | ||
| Platelets, ×106/L | 162 (10) | 159 (9) | 187 (20) | ||
| Sodium, mM | 134 (0) | 134 (0) | 135 (1) | ||
| Potassium, mM | 4.4 (0.1) | 4.3 (0.1) | 4.3 (0.1) | ||
| Creatinine, μM | 72.2 (2.7) | 66.1 (2.3) | 71.9 (4.8) | ||
| Glucose, mM* | 5.8 (0.2) | 5.6 (0.2) | 5.0 (0.3) | ||
| pH* | 7.28 (0.01) | 7.28 (0.01) | 7.27 (0.01) | ||
| Bicarbonate, mM* | 13.13 (0.33) | 13.83 (0.29) | 12.85 (0.55) | ||
| Base deficit, mM* | 12.06 (0.43) | 11.24 (0.35) | 12.22 (0.67) | ||
| Parasitemia, log10 value/μL | 4.8 (4.5-5.0) | 4.6 (4.4-4.7) | 4.6 (4.5-4.8) | ||
No significant differences were seen with regard to any hematologic or biochemical characteristics with the exception of MCV (F = 23.21; P < .001).
Not available for all children; the number of case patients is the same as in Table 1