Odds ratios for malaria-specific syndromes by α+ thalassemia genotype
Groups . | -α/αα (95% CI)* . | P* . | -α/-α (95% CI)* . | P* . |
|---|---|---|---|---|
| All severe malaria | 0.76 (0.59-0.96) | .02 | 0.60 (0.44-0.85) | .004 |
| All severe malaria, adjusted† | 0.73 (0.57-0.94) | .013 | 0.57 (0.40-0.81) | .002 |
| Severe malaria syndromes‡ | ||||
| Prostration | 0.81 (0.59-1.10) | .18 | 0.61 (0.39-0.96) | .03 |
| Coma | 0.70 (0.51-0.97) | .03 | 0.49 (0.31-0.79) | .003 |
| Deep breathing | 0.75 (0.54-1.04) | .08 | 0.64 (0.40-1.03) | .06 |
| Coma and deep breathing | 0.81 (0.50-1.30) | .39 | 0.41 (0.19-0.93) | .03 |
| Symptomatic SMA | 0.63 (0.43-0.93) | .02 | 0.39 (0.21-0.74) | .004 |
| Acidosis | 0.68 (0.51-0.90) | .006 | 0.60 (0.41-0.89) | .01 |
| Hypoglycemia | 0.68 (0.42-1.10) | .11 | 0.75 (0.40-1.40) | .38 |
| Fatal outcome | 0.60 (0.37-1.00) | .05 | 0.37 (0.16-0.87) | .02 |
Groups . | -α/αα (95% CI)* . | P* . | -α/-α (95% CI)* . | P* . |
|---|---|---|---|---|
| All severe malaria | 0.76 (0.59-0.96) | .02 | 0.60 (0.44-0.85) | .004 |
| All severe malaria, adjusted† | 0.73 (0.57-0.94) | .013 | 0.57 (0.40-0.81) | .002 |
| Severe malaria syndromes‡ | ||||
| Prostration | 0.81 (0.59-1.10) | .18 | 0.61 (0.39-0.96) | .03 |
| Coma | 0.70 (0.51-0.97) | .03 | 0.49 (0.31-0.79) | .003 |
| Deep breathing | 0.75 (0.54-1.04) | .08 | 0.64 (0.40-1.03) | .06 |
| Coma and deep breathing | 0.81 (0.50-1.30) | .39 | 0.41 (0.19-0.93) | .03 |
| Symptomatic SMA | 0.63 (0.43-0.93) | .02 | 0.39 (0.21-0.74) | .004 |
| Acidosis | 0.68 (0.51-0.90) | .006 | 0.60 (0.41-0.89) | .01 |
| Hypoglycemia | 0.68 (0.42-1.10) | .11 | 0.75 (0.40-1.40) | .38 |
| Fatal outcome | 0.60 (0.37-1.00) | .05 | 0.37 (0.16-0.87) | .02 |
Because children may manifest multiple complications of severe malaria, some subjects contributed data to more than 1 clinical subgroup.
Compared with normal genotype, analyzed by logistic regression
Adjusted for minor ethnic group within the Mijikenda tribe, sex, and age
Defined as in Table 1; all ORs were adjusted for minor ethnic groups within the Mijikenda tribe, sex, and age2