Analyses of mice transplanted with distinct FGFR3 (K650E) TDII variants
. | No. diseased/no. transplanted . | Latency, d/median . | Spleen weight, mg/median . | WBC, 106/mL/median . |
|---|---|---|---|---|
| FGFR3 TDII | 16/16 | 28-42/35.5 | 381-864/517.5 | 6.1-28.5/15 |
| TDII Y577F | 8/8 | 52-70/60 | 165-711/340 | 2-13.5/7 |
| TDII Y724F | 12/12 | 39-52/42 | 318-682/396 | 5-22.5/10.25 |
| TDII Y760F | 8/8 | 55-73/69.5 | 230-714/304 | 5.5-18/11.25 |
| TDII Y770F | 8/8 | 36-46/44 | 175-534/301.5 | 0.82-15.13/3.54 |
| TDII 2F | 8/8 | 56-76/72 | 326-667/506.5 | 1.5-9/2.25 |
| TDII 3F | 12/12 | 41-102/65.6 | 89.3-423.2/319 | 2-67/7.5 |
| TDII 4F | 8/8 | 70-108/96.5 | 181-512/300 | 2.5-19.4/12.7 |
| TDII FF4F | 0/12 | NA/ > 180 | 71-97.2/90 | 1.8-7.8/3.6 |
. | No. diseased/no. transplanted . | Latency, d/median . | Spleen weight, mg/median . | WBC, 106/mL/median . |
|---|---|---|---|---|
| FGFR3 TDII | 16/16 | 28-42/35.5 | 381-864/517.5 | 6.1-28.5/15 |
| TDII Y577F | 8/8 | 52-70/60 | 165-711/340 | 2-13.5/7 |
| TDII Y724F | 12/12 | 39-52/42 | 318-682/396 | 5-22.5/10.25 |
| TDII Y760F | 8/8 | 55-73/69.5 | 230-714/304 | 5.5-18/11.25 |
| TDII Y770F | 8/8 | 36-46/44 | 175-534/301.5 | 0.82-15.13/3.54 |
| TDII 2F | 8/8 | 56-76/72 | 326-667/506.5 | 1.5-9/2.25 |
| TDII 3F | 12/12 | 41-102/65.6 | 89.3-423.2/319 | 2-67/7.5 |
| TDII 4F | 8/8 | 70-108/96.5 | 181-512/300 | 2.5-19.4/12.7 |
| TDII FF4F | 0/12 | NA/ > 180 | 71-97.2/90 | 1.8-7.8/3.6 |
NA indicates not applicable.