Hematologic malignancy in NHD13 transgenic mice on a C57B16 background
ID . | Age, mo . | Necropsy findings . | WBC, 109/L . | Hb, g/dL . | MCV, fL . | Platelets, 109/L . | Blasts, %* . | Diagnosis . |
|---|---|---|---|---|---|---|---|---|
| 63 | 10 | Hepatosplenomegaly | 51.52 | 2.5 | 63.0 | 126 | 49.2 | Myeloid leukemia with maturation |
| 251 | 9 | Hepatosplenomegaly | 71.9 | 4.7 | 60.8 | 245 | 48.0 | Myeloid leukemia with maturation |
| 254 | 11 | Splenomegaly | 10.72 | 7.1 | 52.9 | 347 | 38.8 | Myeloid leukemia with maturation |
| 1196 | 10 | No remarkable findings | 1.58 | 4.8 | 65.8 | 536 | 16.8 | MDS |
| 2552† | 8 | Hepatosplenomegaly | 2.54 | 11.6 | 51.9 | 516 | ND | Undifferentiated leukemia |
| 2553 | 9 | Hepatosplenomegaly | 170.1 | 7.1 | 69.1 | 346 | 79.0 | Pre-T LBL |
| 1892 | 10 | Hepatosplenomegaly | 3.94 | 9.0 | 73.6 | 677 | 5.5 | MPD-like leukemia |
| 2413 | 7 | Hepatosplenomegaly | 162.9 | 8.2 | 66.6 | 292 | 97.6 | Undifferentiated leukemia |
| 2416 | 9 | Pulmonary hemorrhage | 2.08 | 11.2 | 66.2 | 1058 | 30.0 | Pre-B LBL |
| 2417 | 8 | Hepatosplenomegaly | — | — | — | — | ND | Undifferentiated leukemia |
| 2423 | 7 | Hepatosplenomegaly | — | — | — | — | ND | Biphenotypic leukemia |
| 2554† | 12 | Hepatosplenomegaly | 2.48 | 11.6 | 61.4 | 216 | ND | Myeloid leukemia with maturation |
| 2410 | 10 | Hepatosplenomegaly | 3.14 | 9.2 | 64.3 | 931 | 75.0 | Pre-T LBL |
ID . | Age, mo . | Necropsy findings . | WBC, 109/L . | Hb, g/dL . | MCV, fL . | Platelets, 109/L . | Blasts, %* . | Diagnosis . |
|---|---|---|---|---|---|---|---|---|
| 63 | 10 | Hepatosplenomegaly | 51.52 | 2.5 | 63.0 | 126 | 49.2 | Myeloid leukemia with maturation |
| 251 | 9 | Hepatosplenomegaly | 71.9 | 4.7 | 60.8 | 245 | 48.0 | Myeloid leukemia with maturation |
| 254 | 11 | Splenomegaly | 10.72 | 7.1 | 52.9 | 347 | 38.8 | Myeloid leukemia with maturation |
| 1196 | 10 | No remarkable findings | 1.58 | 4.8 | 65.8 | 536 | 16.8 | MDS |
| 2552† | 8 | Hepatosplenomegaly | 2.54 | 11.6 | 51.9 | 516 | ND | Undifferentiated leukemia |
| 2553 | 9 | Hepatosplenomegaly | 170.1 | 7.1 | 69.1 | 346 | 79.0 | Pre-T LBL |
| 1892 | 10 | Hepatosplenomegaly | 3.94 | 9.0 | 73.6 | 677 | 5.5 | MPD-like leukemia |
| 2413 | 7 | Hepatosplenomegaly | 162.9 | 8.2 | 66.6 | 292 | 97.6 | Undifferentiated leukemia |
| 2416 | 9 | Pulmonary hemorrhage | 2.08 | 11.2 | 66.2 | 1058 | 30.0 | Pre-B LBL |
| 2417 | 8 | Hepatosplenomegaly | — | — | — | — | ND | Undifferentiated leukemia |
| 2423 | 7 | Hepatosplenomegaly | — | — | — | — | ND | Biphenotypic leukemia |
| 2554† | 12 | Hepatosplenomegaly | 2.48 | 11.6 | 61.4 | 216 | ND | Myeloid leukemia with maturation |
| 2410 | 10 | Hepatosplenomegaly | 3.14 | 9.2 | 64.3 | 931 | 75.0 | Pre-T LBL |
MDS indicates myelodysplastic syndrome; ND, not done because the mice were found dead; Pre-T LBL, precursor T-cell lymphoblastic lymphoma/leukemia; MPD, myeloproliferative disorder.
Percentage of blasts in bone marrow or spleen (2413)
Mice found dead. CBC listed is the most recent prior to death (7 or 9 months)