Table 3.

SIRs for parental history of NHL by histopathologic type

Histopathologic type in parents
Histopathologic type in offspring
Diffuse large B-cell
Follicular
B-cell, NOS
T-cell
NHL, NOS
Others
Multiple myeloma
CLL
O
SIR (95% CI)
O
SIR (95% CI)
O
SIR (95% CI)
O
SIR (95% CI)
O
SIR (95% CI)
O
SIR (95% CI)*
O
SIR (95% CI)
O
SIR (95% CI)
NHL  8   4.5 (1.9-8.9)*  8   3.6 (1.5-7.1)*  4   1.6 (0.4-4.1)   5   4.6 (1.5-11.2)*  2   0.51 (0.1-1.9)   7   2.7 (1.1-5.6)*  34   1.2 (0.8-1.6)   25   1.3 (0.9-2.0)  
Diffuse large B-cell   3   11.8 (2.2-34.8)*  0   —   0   —   1   6.5 (0-37.5)   0   —   0   —   6   1.6 (0.6-2.4)   0   —  
Follicular   0   —   3   6.1 (1.1-18.0)*  0   —   2   8.7 (0.8-32.1)   0   —   1   1.7 (0-9.9)   8   1.2 (0.5-2.4)   7   1.7 (0.6-3.4)  
B-cell, NOS   2   7.2 (0.7-26.7)   1   2.8 (0-16.1)   2   4.9 (0.5-17.9)   0   —   1   1.6 (0-9.0)   3   7.2 (1.4-21.2)*  5   1.0 (0.2-2.4)   3   0.9 (0.2-2.8)  
T-cell   1   6.6 (0-38.1)   0   —   0   —   0   —   0   —   0   —   4   1.8 (0.5-4.6)   1   0.7 (0-3.9)  
NHL, NOS   0   —   3   6.9 (1.3-20.4)*  0   —   1   4.8 (0-27.5)   1   1.3 (0-7.2)   0   —   6   1.0 (0.4-2.2)   6   1.5 (0.6-3.4)  
Others   2   6.0 (0.6-22.1)   1   2.3 (0-13.2)   2   4.2 (0.4-15.3)   1   5.0 (0-28.5)   0   —   3   6.3 (1.2-18.5)*  5   0.9 (0.3-2.2)   8   2.3 (1.0-4.6)  
Multiple myeloma  0   —   0   —   0   —   0   —   0   —   0   —   21   2.3 (1.4-3.5)*  8   1.4 (0.6-2.7)  
Plasma cell   0   —   0   —   0   —   0   —   0   —   0   —   21   2.5 (1.5-3.8)*  8   1.4 (0.6-2.9)  
Plasmacytoma, NOS   0   —   0   —   0   —   0   —   0   —   0   —   0   —   0   —  
CLL  0   —   1   2.5 (0-14.5)   0   —   0   —   3   3.7 (0.7-11.0)   0   —   9   1.3 (0.6-2.4)   27   5.9 (3.9-8.6)* 
P†
 
 		 .069
 
 		 .137
 
 		 .380
 
 		 —
 
 		 .820
 
 		 .481
 
 		 .014
 
 		 <.001
 
Histopathologic type in parents
Histopathologic type in offspring
Diffuse large B-cell
Follicular
B-cell, NOS
T-cell
NHL, NOS
Others
Multiple myeloma
CLL
O
SIR (95% CI)
O
SIR (95% CI)
O
SIR (95% CI)
O
SIR (95% CI)
O
SIR (95% CI)
O
SIR (95% CI)*
O
SIR (95% CI)
O
SIR (95% CI)
NHL  8   4.5 (1.9-8.9)*  8   3.6 (1.5-7.1)*  4   1.6 (0.4-4.1)   5   4.6 (1.5-11.2)*  2   0.51 (0.1-1.9)   7   2.7 (1.1-5.6)*  34   1.2 (0.8-1.6)   25   1.3 (0.9-2.0)  
Diffuse large B-cell   3   11.8 (2.2-34.8)*  0   —   0   —   1   6.5 (0-37.5)   0   —   0   —   6   1.6 (0.6-2.4)   0   —  
Follicular   0   —   3   6.1 (1.1-18.0)*  0   —   2   8.7 (0.8-32.1)   0   —   1   1.7 (0-9.9)   8   1.2 (0.5-2.4)   7   1.7 (0.6-3.4)  
B-cell, NOS   2   7.2 (0.7-26.7)   1   2.8 (0-16.1)   2   4.9 (0.5-17.9)   0   —   1   1.6 (0-9.0)   3   7.2 (1.4-21.2)*  5   1.0 (0.2-2.4)   3   0.9 (0.2-2.8)  
T-cell   1   6.6 (0-38.1)   0   —   0   —   0   —   0   —   0   —   4   1.8 (0.5-4.6)   1   0.7 (0-3.9)  
NHL, NOS   0   —   3   6.9 (1.3-20.4)*  0   —   1   4.8 (0-27.5)   1   1.3 (0-7.2)   0   —   6   1.0 (0.4-2.2)   6   1.5 (0.6-3.4)  
Others   2   6.0 (0.6-22.1)   1   2.3 (0-13.2)   2   4.2 (0.4-15.3)   1   5.0 (0-28.5)   0   —   3   6.3 (1.2-18.5)*  5   0.9 (0.3-2.2)   8   2.3 (1.0-4.6)  
Multiple myeloma  0   —   0   —   0   —   0   —   0   —   0   —   21   2.3 (1.4-3.5)*  8   1.4 (0.6-2.7)  
Plasma cell   0   —   0   —   0   —   0   —   0   —   0   —   21   2.5 (1.5-3.8)*  8   1.4 (0.6-2.9)  
Plasmacytoma, NOS   0   —   0   —   0   —   0   —   0   —   0   —   0   —   0   —  
CLL  0   —   1   2.5 (0-14.5)   0   —   0   —   3   3.7 (0.7-11.0)   0   —   9   1.3 (0.6-2.4)   27   5.9 (3.9-8.6)* 
P†
 
 		 .069
 
 		 .137
 
 		 .380
 
 		 —
 
 		 .820
 
 		 .481
 
 		 .014
 
 		 <.001
 

O indicates number of observed cases CLL, chronic lymphocytic leukemia; and —, not determined.

*

95% CI does not include 1.00.

†

P values represent parental/offspring concordant malignancy compared with all other subtypes.

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