SIRs for familial history of NHL by sex
. | Any first-degree relative . | . | Parents only . | . | Siblings only . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Histopathologic subtype . | O . | SIR (95% CI) . | O . | SIR (95% CI) . | O . | SIR (95% CI) . | |||
| Men | |||||||||
| NHL | 61 | 1.6 (1.2-2.0)* | 51 | 1.7 (1.2-2.2)* | 10 | 1.2 (0.4-2.7) | |||
| Diffuse large B-cell | 10 | 1.9 (0.9-3.4) | 10 | 2.3 (1.0-4.3) | 0 | — | |||
| Follicular | 14 | 1.8 (1.0-3.1) | 13 | 2.1 (1.0-3.8) | 1 | 0.6 (0-3.5) | |||
| B-cell, NOS | 8 | 1.3 (0.5-2.5) | 6 | 1.2 (0.4-2.7) | 2 | 1.4 (0.1-5.3) | |||
| T-cell | 1 | 0.3 (0-1.7) | 0 | — | 1 | 1.5 (0-8.5) | |||
| NHL, NOS | 10 | 1.2 (0.6-2.3) | 8 | 1.3 (0.5-2.5) | 2 | 1.1 (0.1-4.2) | |||
| Others | 18 | 2.1 (1.3-3.4)* | 14 | 2.1 (1.0-3.5) | 4 | 2.3 (0.6-5.8) | |||
| Multiple myeloma | 10 | 0.9 (0.4-1.6) | 6 | 0.7 (0.2-1.5) | 3 | 1.15 (0.2-3.4) | |||
| Plasma cell | 9 | 0.7 (0.4-1.6) | 5 | 0.6 (0.2-1.4) | 3 | 1.22 (0.2-3.6) | |||
| Plasmacytoma, NOS | 1 | 1.3 (0-7.2) | 1 | 1.6 (0-9.1) | 0 | — | |||
| CLL | 14 | 1.4 (0.8-2.4) | 11 | 1.4 (0.7-2.6) | 3 | 1.32 (0.3-3.9) | |||
| Women | |||||||||
| NHL | 54 | 2.3 (1.7-2.9)* | 38 | 2.0 (1.4-2.8)* | 16 | 3.1 (1.3-5.9)* | |||
| Diffuse large B-cell | 5 | 1.7 (0.5-4.0) | 5 | 2.2 (0.7-5.1) | 0 | — | |||
| Follicular | 15 | 2.3 (1.3-3.8)* | 9 | 1.8 (0.8-3.3) | 6 | 4.2 (1.5-9.3)* | |||
| B-cell, NOS | 11 | 2.5 (1.2-4.4)* | 5 | 1.4 (0.5-3.4) | 6 | 6.3 (2.3-13.9)* | |||
| T-cell | 4 | 2.3 (0.6-5.8) | 4 | 2.9 (0.8-7.4) | 0 | — | |||
| NHL, NOS | 12 | 2.5 (1.3-4.3)* | 10 | 2.6 (1.3-4.9)* | 2 | 1.8 (0.2-6.7) | |||
| Others | 7 | 2.1 (0.8-4.4) | 5 | 1.9 (0.6-4.6) | 2 | 2.8 (0.3-10.2) | |||
| Multiple myeloma | 3 | 0.4 (0.1-1.2) | 2 | 0.3 (0-1.3) | 1 | 0.6 (0-3.3) | |||
| Plasma cell | 3 | 0.4 (0.1-1.2) | 2 | 0.4 (0-1.3) | 1 | 0.6 (0-3.4) | |||
| Plasmacytoma, NOS | 0 | — | 0 | — | 0 | — | |||
| CLL | 11 | 2.2 (1.1-3.4)* | 9 | 2.3 (1.1-4.4)* | 2 | 1.8 (0.2-6.5) | |||
. | Any first-degree relative . | . | Parents only . | . | Siblings only . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Histopathologic subtype . | O . | SIR (95% CI) . | O . | SIR (95% CI) . | O . | SIR (95% CI) . | |||
| Men | |||||||||
| NHL | 61 | 1.6 (1.2-2.0)* | 51 | 1.7 (1.2-2.2)* | 10 | 1.2 (0.4-2.7) | |||
| Diffuse large B-cell | 10 | 1.9 (0.9-3.4) | 10 | 2.3 (1.0-4.3) | 0 | — | |||
| Follicular | 14 | 1.8 (1.0-3.1) | 13 | 2.1 (1.0-3.8) | 1 | 0.6 (0-3.5) | |||
| B-cell, NOS | 8 | 1.3 (0.5-2.5) | 6 | 1.2 (0.4-2.7) | 2 | 1.4 (0.1-5.3) | |||
| T-cell | 1 | 0.3 (0-1.7) | 0 | — | 1 | 1.5 (0-8.5) | |||
| NHL, NOS | 10 | 1.2 (0.6-2.3) | 8 | 1.3 (0.5-2.5) | 2 | 1.1 (0.1-4.2) | |||
| Others | 18 | 2.1 (1.3-3.4)* | 14 | 2.1 (1.0-3.5) | 4 | 2.3 (0.6-5.8) | |||
| Multiple myeloma | 10 | 0.9 (0.4-1.6) | 6 | 0.7 (0.2-1.5) | 3 | 1.15 (0.2-3.4) | |||
| Plasma cell | 9 | 0.7 (0.4-1.6) | 5 | 0.6 (0.2-1.4) | 3 | 1.22 (0.2-3.6) | |||
| Plasmacytoma, NOS | 1 | 1.3 (0-7.2) | 1 | 1.6 (0-9.1) | 0 | — | |||
| CLL | 14 | 1.4 (0.8-2.4) | 11 | 1.4 (0.7-2.6) | 3 | 1.32 (0.3-3.9) | |||
| Women | |||||||||
| NHL | 54 | 2.3 (1.7-2.9)* | 38 | 2.0 (1.4-2.8)* | 16 | 3.1 (1.3-5.9)* | |||
| Diffuse large B-cell | 5 | 1.7 (0.5-4.0) | 5 | 2.2 (0.7-5.1) | 0 | — | |||
| Follicular | 15 | 2.3 (1.3-3.8)* | 9 | 1.8 (0.8-3.3) | 6 | 4.2 (1.5-9.3)* | |||
| B-cell, NOS | 11 | 2.5 (1.2-4.4)* | 5 | 1.4 (0.5-3.4) | 6 | 6.3 (2.3-13.9)* | |||
| T-cell | 4 | 2.3 (0.6-5.8) | 4 | 2.9 (0.8-7.4) | 0 | — | |||
| NHL, NOS | 12 | 2.5 (1.3-4.3)* | 10 | 2.6 (1.3-4.9)* | 2 | 1.8 (0.2-6.7) | |||
| Others | 7 | 2.1 (0.8-4.4) | 5 | 1.9 (0.6-4.6) | 2 | 2.8 (0.3-10.2) | |||
| Multiple myeloma | 3 | 0.4 (0.1-1.2) | 2 | 0.3 (0-1.3) | 1 | 0.6 (0-3.3) | |||
| Plasma cell | 3 | 0.4 (0.1-1.2) | 2 | 0.4 (0-1.3) | 1 | 0.6 (0-3.4) | |||
| Plasmacytoma, NOS | 0 | — | 0 | — | 0 | — | |||
| CLL | 11 | 2.2 (1.1-3.4)* | 9 | 2.3 (1.1-4.4)* | 2 | 1.8 (0.2-6.5) | |||
O indicates number of observed cases CLL, chronic lymphocytic leukemia; and —, not determined.
95% CI does not include 1.00.