Table 1. Stem and progenitor cell... | American Society of Hematology

Table 1.

Stem and progenitor cell populations in RunxI^F/F—Tg(Mx1-Cre) BM

		Genotype
		Runx1^F/F			Runx1^F/F—Tg(Mx1-Cre)
Cell type	Marker content	BM, %, mean ± SD*	No. mice	BM, %, mean ± SD*	No. mice	Fold change	P†
HSC	IL-7Rα^-Lin^-Sca-1^hi c-Kit^hi	0.34 ± 0.1	4	0.99 ± 0.5	6	2.9	.011
CLP	IL-7Rα⁺Lin^-Sca-1^lo c-Kit^lo	0.07 ± 0.01	4	<0.01 ± <0.01	6	>-7.0	.019
CMP	IL-7Rα^-Lin^-Sca-1^- c-Kit⁺ CD34⁺ FcγRII/III⁺	0.37 ± 0.1	3	0.30 ± 0.2	4	-0.8	.377‡
GMP	IL-7Rα^-Lin^-Sca-1^- c-Kit⁺ CD34⁺ FcγRII/III^hi	0.67 ± 0.1	3	1.98 ± 0.8	4	3.0	.032

		Genotype
		Runx1^F/F			Runx1^F/F—Tg(Mx1-Cre)
Cell type	Marker content	BM, %, mean ± SD*	No. mice	BM, %, mean ± SD*	No. mice	Fold change	P†
HSC	IL-7Rα^-Lin^-Sca-1^hi c-Kit^hi	0.34 ± 0.1	4	0.99 ± 0.5	6	2.9	.011
CLP	IL-7Rα⁺Lin^-Sca-1^lo c-Kit^lo	0.07 ± 0.01	4	<0.01 ± <0.01	6	>-7.0	.019
CMP	IL-7Rα^-Lin^-Sca-1^- c-Kit⁺ CD34⁺ FcγRII/III⁺	0.37 ± 0.1	3	0.30 ± 0.2	4	-0.8	.377‡
GMP	IL-7Rα^-Lin^-Sca-1^- c-Kit⁺ CD34⁺ FcγRII/III^hi	0.67 ± 0.1	3	1.98 ± 0.8	4	3.0	.032

Percentage of total BM. Detection limit is 0.01%. Data are results from 17, 27, and 39 weeks after pIpC.

Mann-Whitney U test.

Not statistically different.