Quantitative analysis of platelet-endothelial cell interactions
. | Sham, mean ± SEM . | I/R, mean ± SEM . | . | |
|---|---|---|---|---|
. | JAM-A+/+ platelets, JAM A+/+ mice . | JAM-A+/+ platelets, JAM-A+/+ mice . | JAM-A−/− platelets, JAM-A+/+ mice . | |
| Postsinusoidal venules, cells/mm2 | 68.7 ± 5.1 | 537.9 ± 24.9* | 413.0 ± 64.5* | |
| Sinusoids, cells/acinus | 2.1 ± 0.1 | 11.5 ± 0.4* | 12.1 ± 0.6* | |
. | Sham, mean ± SEM . | I/R, mean ± SEM . | . | |
|---|---|---|---|---|
. | JAM-A+/+ platelets, JAM A+/+ mice . | JAM-A+/+ platelets, JAM-A+/+ mice . | JAM-A−/− platelets, JAM-A+/+ mice . | |
| Postsinusoidal venules, cells/mm2 | 68.7 ± 5.1 | 537.9 ± 24.9* | 413.0 ± 64.5* | |
| Sinusoids, cells/acinus | 2.1 ± 0.1 | 11.5 ± 0.4* | 12.1 ± 0.6* | |
The number of either wild-type (JAM-A+/+) or JAM-A−/− platelets accumulated in hepatic microvessels in sham-operated mice and in mice after 90 minutes of ischemia and 30 minutes of reperfusion, n = 5 each group.
P < .05 versus sham.