Human tissue samples analyzed by immunohistochemistry and subjected to nested PCR analysis for detection of C μ deletion after DNA extraction
Tissue category and clinicopathologic information . | No. of individual samples . | Subject median age, y (range) . |
|---|---|---|
| Subjects without IgA deficiency | ||
| Palatine tonsils | ||
| Normal controls | 9 | 10 (2-72) |
| Recurrent tonsillitis | 13 | 5 (3-75) |
| Nasopharyngeal tonsil (adenoids) | ||
| Normal controls | 5 | 6 (2-10) |
| Adenoid hyperplasia | 10 | 6.5 (3-60) |
| Lacrimal glands, normal | 6 | 31 (6-65) |
| Salivary glands, normal parotid and submandibular | 8 | 33.5 (25-73) |
| Nasal mucosa, normal or slightly inflamed | 16 | 42 (6-70) |
| Small bowel mucosa | ||
| Normal duodenum | 2 | 21-35 |
| Duodenum with celiac disease | 11 | 49 (29-64) |
| Normal ileum | 6 | 16 (7-39) |
| Ileum with Crohn disease | 3 | 36 (27-47) |
| Large bowel mucosa | ||
| Normal | 8 | 45 (7-70) |
| Ulcerative colitis or Crohn disease | 7 | 29 (24-43) |
| Peyer patches, normal | 7 | 20 (7-39) |
| Cervical lymph nodes, slight reactive changes | 8 | 14 (1-30) |
| Inguinal lymph nodes, slight reactive changes | 5 | 38 (26-45) |
| Mesenteric lymph nodes, slight reactive changes | 7 | 20 (7-39) |
| Bone marrow, normal | 6 | 6 (5-7) |
| Uterine cervix mucosa, normal or slightly inflamed | 5 | 43 (27-45) |
| Subjects with selective IgA deficiency | ||
| Adenoids, hyperplastic | 1 | 5 |
| Palatine tonsil, recurrent tonsillitis | 2 | 5-20 |
| Lacrimal gland, normal | 1 | 53 |
| Salivary (parotid) gland, normal | 1 | 25 |
| Nasal mucosa, normal or slightly inflamed | 26 | 31.5 (5-65) |
| Small bowel mucosa | ||
| Normal duodenum | 22 | 33 (2-67) |
| Duodenum with celiac disease | 1 | 12 |
| Large bowel mucosa, normal | 3 | 11 (1-35) |
Tissue category and clinicopathologic information . | No. of individual samples . | Subject median age, y (range) . |
|---|---|---|
| Subjects without IgA deficiency | ||
| Palatine tonsils | ||
| Normal controls | 9 | 10 (2-72) |
| Recurrent tonsillitis | 13 | 5 (3-75) |
| Nasopharyngeal tonsil (adenoids) | ||
| Normal controls | 5 | 6 (2-10) |
| Adenoid hyperplasia | 10 | 6.5 (3-60) |
| Lacrimal glands, normal | 6 | 31 (6-65) |
| Salivary glands, normal parotid and submandibular | 8 | 33.5 (25-73) |
| Nasal mucosa, normal or slightly inflamed | 16 | 42 (6-70) |
| Small bowel mucosa | ||
| Normal duodenum | 2 | 21-35 |
| Duodenum with celiac disease | 11 | 49 (29-64) |
| Normal ileum | 6 | 16 (7-39) |
| Ileum with Crohn disease | 3 | 36 (27-47) |
| Large bowel mucosa | ||
| Normal | 8 | 45 (7-70) |
| Ulcerative colitis or Crohn disease | 7 | 29 (24-43) |
| Peyer patches, normal | 7 | 20 (7-39) |
| Cervical lymph nodes, slight reactive changes | 8 | 14 (1-30) |
| Inguinal lymph nodes, slight reactive changes | 5 | 38 (26-45) |
| Mesenteric lymph nodes, slight reactive changes | 7 | 20 (7-39) |
| Bone marrow, normal | 6 | 6 (5-7) |
| Uterine cervix mucosa, normal or slightly inflamed | 5 | 43 (27-45) |
| Subjects with selective IgA deficiency | ||
| Adenoids, hyperplastic | 1 | 5 |
| Palatine tonsil, recurrent tonsillitis | 2 | 5-20 |
| Lacrimal gland, normal | 1 | 53 |
| Salivary (parotid) gland, normal | 1 | 25 |
| Nasal mucosa, normal or slightly inflamed | 26 | 31.5 (5-65) |
| Small bowel mucosa | ||
| Normal duodenum | 22 | 33 (2-67) |
| Duodenum with celiac disease | 1 | 12 |
| Large bowel mucosa, normal | 3 | 11 (1-35) |