IRP2-/- and IRP1+/- IRP2-/- mice have normal or slightly elevated transferrin saturations, and high serum ferritins
. | IRP1+/+ IRP2+/+ . | IRP1+/+ IRP2-/- . | IRP1+/- IRP2-/- . |
|---|---|---|---|
| Serum iron, μg/dL | 118 ± 16 | 121 ± 26 | 184 ± 25 |
| TIBC, μg/dL | 305 ± 30 | 278 ± 40 | 389 ± 39 |
| Transferrin saturation, % | 39 ± 6 | 44 ± 11 | 48 ± 10 |
| Serum ferritin, ng/mL | 182 ± 61 | 1283 ± 514 | 1547 ± 562 |
. | IRP1+/+ IRP2+/+ . | IRP1+/+ IRP2-/- . | IRP1+/- IRP2-/- . |
|---|---|---|---|
| Serum iron, μg/dL | 118 ± 16 | 121 ± 26 | 184 ± 25 |
| TIBC, μg/dL | 305 ± 30 | 278 ± 40 | 389 ± 39 |
| Transferrin saturation, % | 39 ± 6 | 44 ± 11 | 48 ± 10 |
| Serum ferritin, ng/mL | 182 ± 61 | 1283 ± 514 | 1547 ± 562 |
Serum iron, TIBC, transferrin saturation and serum ferritin were measured and calculated as described in materials and methods. Serum iron, TIBC and transferrin saturations did not differ significantly between WT and control. However, serum iron and TIBC were significantly elevated in the IRP1+/- IRP2-/- mice relative to WT (for serum iron, P < .001; for TIBC, P < .001). Transferrin saturations were not significantly different from WT for IRP2-/- mice, but were slightly but significantly elevated in IRP1+/- IRP2-/- mice relative to WT (P = .047). Serum ferritins were elevated in the IRP2-/- mice (P = .02) and more elevated in the IRP1+/- IRP2-/- mice relative to WT (P < .001). Data presented as mean values ± standard deviation.