Table 1. Genes involved in V(D)J... | American Society of Hematology

Table 1.

Genes involved in V(D)J recombination.

Gene	Properties	Role in V(D)J Recombination	Other Roles
Rag-1	Endonuclease	Initiation	None known
Rag-2	Endonuclease	Initiation	None known
DNA-PKcs	Protein kinase	Rejoining coding ends	Switch recombination
Ku70	DNA end-binding;	Rejoining coding and signal ends	NHEJ pathway; Growth
Ku80	DNA end-binding; TdT recruitment	Rejoining coding and signal ends	NHEJ pathway; Growth
XRCC4	Activates DNA ligase	Rejoining coding and signal ends	NHEJ pathway; Brain development
DNA Ligase IV	End joining	Rejoining coding and signal ends	NHEJ pathway; Brain development
TdT	Nucleotide addition	Diversifies coding joins	None known

Gene	Properties	Role in V(D)J Recombination	Other Roles
Rag-1	Endonuclease	Initiation	None known
Rag-2	Endonuclease	Initiation	None known
DNA-PKcs	Protein kinase	Rejoining coding ends	Switch recombination
Ku70	DNA end-binding;	Rejoining coding and signal ends	NHEJ pathway; Growth
Ku80	DNA end-binding; TdT recruitment	Rejoining coding and signal ends	NHEJ pathway; Growth
XRCC4	Activates DNA ligase	Rejoining coding and signal ends	NHEJ pathway; Brain development
DNA Ligase IV	End joining	Rejoining coding and signal ends	NHEJ pathway; Brain development
TdT	Nucleotide addition	Diversifies coding joins	None known