Table 2. Gene deficiencies that confer... | American Society of Hematology

Table 2.

Gene deficiencies that confer susceptibility to antigen receptor translocations in lymphoma.

Gene	Function	Species	Lymphoma Type	Translocation
ATM	DNA damage response	Human	T-NHL; T-PLL	t(7;14)
ATM	DNA damage response	Mice	Thymic	Multiple
NBS1	DNA damage response	Human	B-NHL; T-NHL	Unknown
BLM	Chromosomal maintenance	Human	NHL	Unknown
^*p53	DNA damage response	Mice	Pro-B	t(12;15) IgH-cmyc
^**DNA-PKcs	Rejoin V(D)J coding ends	Mice	Pro-B	t(12;15) IgH-cmyc t(12;12) IgH-nmyc
^**XRCC4	NHEJ pathway	Mice	Pro-B	t(12;15) IgH-cmyc
^**Ku86	NHEJ pathway	Mice	Pro-B	t(12;15) IgH-cmyc

Gene	Function	Species	Lymphoma Type	Translocation
ATM	DNA damage response	Human	T-NHL; T-PLL	t(7;14)
ATM	DNA damage response	Mice	Thymic	Multiple
NBS1	DNA damage response	Human	B-NHL; T-NHL	Unknown
BLM	Chromosomal maintenance	Human	NHL	Unknown
^*p53	DNA damage response	Mice	Pro-B	t(12;15) IgH-cmyc
^**DNA-PKcs	Rejoin V(D)J coding ends	Mice	Pro-B	t(12;15) IgH-cmyc t(12;12) IgH-nmyc
^**XRCC4	NHEJ pathway	Mice	Pro-B	t(12;15) IgH-cmyc
^**Ku86	NHEJ pathway	Mice	Pro-B	t(12;15) IgH-cmyc

^*

in combination with deficiency of V(D)J rejoining components DNA-PKcs, Ku86, or XRCC4.

when combined with p53-null mutation.