Table 3. Pretreatment variables... | American Society of Hematology

Table 3.

Pretreatment variables correlating with a response to immunosuppression.

Favorable Factors	Significant Correlation in Univariate Analysis (p < 0.05)	Significant Correlation in Multivariate Analysis (p < 0.05)	Odds in Multivariate Predictive Model
Younger age	yes	yes	2X less likely to respond with each 5 year increase in age
Shorter duration of red cell transfusion dependence (RCTD)	yes	yes	1.5X less likely to respond with each 3 month increase in RCTD
Positive for HLA DRB1 15	yes	yes	9.9X more likely to respond if HLA DRB1 15 positive
Decreased cellularity of bone marrow	yes	no
Increased number of cytopenias	yes	no
< 5% marrow blasts	yes	no
Normal cytogenetics	yes	no
PNH present by flow	yes	no
Low IPSS score	no	no

Favorable Factors	Significant Correlation in Univariate Analysis (p < 0.05)	Significant Correlation in Multivariate Analysis (p < 0.05)	Odds in Multivariate Predictive Model
Younger age	yes	yes	2X less likely to respond with each 5 year increase in age
Shorter duration of red cell transfusion dependence (RCTD)	yes	yes	1.5X less likely to respond with each 3 month increase in RCTD
Positive for HLA DRB1 15	yes	yes	9.9X more likely to respond if HLA DRB1 15 positive
Decreased cellularity of bone marrow	yes	no
Increased number of cytopenias	yes	no
< 5% marrow blasts	yes	no
Normal cytogenetics	yes	no
PNH present by flow	yes	no
Low IPSS score	no	no