Proposed critical variable in marrow-to-muscle conversion
Factor . | Effects . |
|---|---|
| Presence of injury | Minimal conversion without any injury.13 |
| Mobilization | Type and the number of mobilization cycles are important.13 |
| Timing of cell delivery from injury | Injection of cells after injury increase the conversion rate. |
| Cell dose | Increasing the number of the transplanted cells improves the conversion but a plateau may exist. |
| Systemic irradiation with hematopoietic chimerism | Lower doses are beneficial and higher doses are detrimental. |
| Local irradiation | Minimal improvement if any. |
| Typ of transplanted cell | Lineage negative cells and cKit positive and Sca-1 cells are enriched for cells producing GFP + skeletal muscles. |
| Mode of cell delivery | Direct cell delivery by percutaneous injection improves the outcome.13 |
| Cell tracking system/immune status of host | Immunologic reaction to GFP may decrease the conversion because of immunologic rejection. |
Factor . | Effects . |
|---|---|
| Presence of injury | Minimal conversion without any injury.13 |
| Mobilization | Type and the number of mobilization cycles are important.13 |
| Timing of cell delivery from injury | Injection of cells after injury increase the conversion rate. |
| Cell dose | Increasing the number of the transplanted cells improves the conversion but a plateau may exist. |
| Systemic irradiation with hematopoietic chimerism | Lower doses are beneficial and higher doses are detrimental. |
| Local irradiation | Minimal improvement if any. |
| Typ of transplanted cell | Lineage negative cells and cKit positive and Sca-1 cells are enriched for cells producing GFP + skeletal muscles. |
| Mode of cell delivery | Direct cell delivery by percutaneous injection improves the outcome.13 |
| Cell tracking system/immune status of host | Immunologic reaction to GFP may decrease the conversion because of immunologic rejection. |