Onset of IBMTR grades B to D aGVHD and outcomes by week
. | Onset of grades B to D . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Response by week . | Wk 1 n = 45 . | . | Wk 2 n = 78 . | . | Wk 3 n = 79 . | . | Wk 4 n = 54 . | . | Wk 5 n = 39 . | . | Wk 6 n = 22 . | . | Wk 7 n = 18 . | . | Wk 8 n = 11 . | . | Wk 9 n = 7 . | . | Wk 10 n = 3 . | . | |||||||||||||||||||
| . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | |||||||||||||||||||
| Wk 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 2 | 0 | 9 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 3 | 1 | 10 | 3 | 18 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 4 | 0 | 8 | 2 | 18 | 2 | 33 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 5 | 0 | 2 | 2 | 5 | 0 | 14 | 0 | 24 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 6 | 1 | 5 | 0 | 6 | 2 | 7 | 0 | 10 | 0 | 20 | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 7 | 1 | 4 | 3 | 9 | 1 | 4 | 1 | 5 | 1 | 7 | 0 | 8 | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 8 | 0 | 0 | 0 | 1 | 1 | 4 | 1 | 4 | 0 | 2 | 0 | 6 | 0 | 5 | — | — | — | — | — | — | |||||||||||||||||||
| Wk 9 | 0 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 6 | 0 | 4 | — | — | — | — | |||||||||||||||||||
| Wk 10 | 0 | 1 | 1 | 0 | 1 | 2 | 0 | 2 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 2 | — | — | |||||||||||||||||||
| Wk 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||
| Wk 12 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | |||||||||||||||||||
| Wk 13 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 1 | |||||||||||||||||||
| Wk 14 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | |||||||||||||||||||
. | Onset of grades B to D . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Response by week . | Wk 1 n = 45 . | . | Wk 2 n = 78 . | . | Wk 3 n = 79 . | . | Wk 4 n = 54 . | . | Wk 5 n = 39 . | . | Wk 6 n = 22 . | . | Wk 7 n = 18 . | . | Wk 8 n = 11 . | . | Wk 9 n = 7 . | . | Wk 10 n = 3 . | . | |||||||||||||||||||
| . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | |||||||||||||||||||
| Wk 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 2 | 0 | 9 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 3 | 1 | 10 | 3 | 18 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 4 | 0 | 8 | 2 | 18 | 2 | 33 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 5 | 0 | 2 | 2 | 5 | 0 | 14 | 0 | 24 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 6 | 1 | 5 | 0 | 6 | 2 | 7 | 0 | 10 | 0 | 20 | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 7 | 1 | 4 | 3 | 9 | 1 | 4 | 1 | 5 | 1 | 7 | 0 | 8 | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 8 | 0 | 0 | 0 | 1 | 1 | 4 | 1 | 4 | 0 | 2 | 0 | 6 | 0 | 5 | — | — | — | — | — | — | |||||||||||||||||||
| Wk 9 | 0 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 6 | 0 | 4 | — | — | — | — | |||||||||||||||||||
| Wk 10 | 0 | 1 | 1 | 0 | 1 | 2 | 0 | 2 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 2 | — | — | |||||||||||||||||||
| Wk 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||
| Wk 12 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | |||||||||||||||||||
| Wk 13 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 1 | |||||||||||||||||||
| Wk 14 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | |||||||||||||||||||
Other outcomes include patients alive with persistent evidence of aGVHD; there were 2 in week 1, 4 in week 2, 1 in week 3, 3 in week 4, 2 in week 5, 3 in week 6, 0 in week 7, 1 in week 8, 1 in week 9, and 2 in week 10.
D indicates dead; R, resolved (no evidence of GVHD); and-, none.