Onset of Glucksberg grades II to IV aGVHD and outcomes by week
. | Onset of grades II to IV . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Response by week . | Wk 1 n = 38 . | . | Wk 2 n = 63 . | . | Wk 3 n = 59 . | . | Wk 4 n = 41 . | . | Wk 5 n = 22 . | . | Wk 6 n = 13 . | . | Wk 7 n = 14 . | . | Wk 8 n = 12 . | . | Wk 9 n = 6 . | . | Wk 10 n = 4 . | . | |||||||||||||||||||
| . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | |||||||||||||||||||
| Wk 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 2 | 0 | 8 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 3 | 1 | 8 | 3 | 15 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 4 | 0 | 5 | 1 | 15 | 2 | 20 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 5 | 0 | 2 | 2 | 4 | 0 | 12 | 0 | 15 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 6 | 1 | 5 | 0 | 5 | 2 | 3 | 0 | 4 | 0 | 9 | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 7 | 1 | 3 | 2 | 8 | 1 | 4 | 1 | 5 | 0 | 4 | 0 | 4 | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 8 | 0 | 0 | 0 | 0 | 1 | 4 | 1 | 3 | 0 | 1 | 0 | 2 | 0 | 4 | — | — | — | — | — | — | |||||||||||||||||||
| Wk 9 | 0 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 4 | 0 | 4 | — | — | — | — | |||||||||||||||||||
| Wk 10 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | — | — | |||||||||||||||||||
| Wk 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||
| Wk 12 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | 1 | |||||||||||||||||||
| Wk 13 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | |||||||||||||||||||
| Wk 14 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | |||||||||||||||||||
. | Onset of grades II to IV . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Response by week . | Wk 1 n = 38 . | . | Wk 2 n = 63 . | . | Wk 3 n = 59 . | . | Wk 4 n = 41 . | . | Wk 5 n = 22 . | . | Wk 6 n = 13 . | . | Wk 7 n = 14 . | . | Wk 8 n = 12 . | . | Wk 9 n = 6 . | . | Wk 10 n = 4 . | . | |||||||||||||||||||
| . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | D . | R . | |||||||||||||||||||
| Wk 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 2 | 0 | 8 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 3 | 1 | 8 | 3 | 15 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 4 | 0 | 5 | 1 | 15 | 2 | 20 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 5 | 0 | 2 | 2 | 4 | 0 | 12 | 0 | 15 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 6 | 1 | 5 | 0 | 5 | 2 | 3 | 0 | 4 | 0 | 9 | — | — | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 7 | 1 | 3 | 2 | 8 | 1 | 4 | 1 | 5 | 0 | 4 | 0 | 4 | — | — | — | — | — | — | — | — | |||||||||||||||||||
| Wk 8 | 0 | 0 | 0 | 0 | 1 | 4 | 1 | 3 | 0 | 1 | 0 | 2 | 0 | 4 | — | — | — | — | — | — | |||||||||||||||||||
| Wk 9 | 0 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 4 | 0 | 4 | — | — | — | — | |||||||||||||||||||
| Wk 10 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | — | — | |||||||||||||||||||
| Wk 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||
| Wk 12 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | 1 | |||||||||||||||||||
| Wk 13 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | |||||||||||||||||||
| Wk 14 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | |||||||||||||||||||
Other outcomes include patients alive with persistent evidence of aGVHD; there were 2 in week 1, 5 in week 2, 1 in week 3, 2 each in weeks 4 through 6, 1 each in weeks 7 through 9, and 2 in week 10.
D indicates dead; R, resolved (no evidence of GVHD); and-, none.