Table 1. Phenotype of conditional bcl-x... | American Society of Hematology

Table 1.

Phenotype of conditional bcl-x^−/− and control mice

	*Conditional bcl-x^−/−*	Bled control	Unbled control
Spleen mass, g	5.2 ± 0.8	0.3 ± 0.0^*	0.1 ± 0.0^*
Hemoglobin level, g/dL	4.3 ± 0.5	6.5 ± 0.3^*	15.8 ± 1.3^*
Erythrocyte count, × 10⁶/μL	2.2 ± 0.2	4.1 ± 0.2^*	10.3 ± 0.5^*
MCHC, g/dL	32 ± 0.5	26 ± 0.2^*	33 ± 0.8
Reticulocyte count, × 10⁵/μL	1.5 ± 0.3	14 ± 1.0^*	2.7 ± 0.5^*
Total, %	6.8 ± 0.8	34 ± 1.9^*	2.6 ± 0.5^*
Early, %	55 ± 5	63 ± 3	10 ± 6^*
Middle, %	18 ± 3	21 ± 2	40 ± 2^*
Late, %	27 ± 3	16 ± 2^*	50 ± 7^*
MCV, fL	60 ± 1.2	58 ± 1.0	47 ± 2.0^*
Mature, fL	59 ± 1.4	48 ± 0.4^*	47 ± 1.5^*
Retic, fL	75 ± 1.2	76 ± 1.4	55 ± 1.9^*
RDW, %	20 ± 0.9	31 ± 0.2^*	12 ± 0.9^*
Mature, %	17 ± 0.9	15 ± 0.3^*	12 ± 0.2^*
Retic, %	15 ± 1.0	17 ± 0.2	11 ± 0.2^*
Bilirubin levels
Total, mg/dL	5.6 ± 1.3	0.2 ± 0.1^*	0.3 ± 0.1^*
Indirect, mg/dL	4.6 ± 1.0	0.1 ± 0.0^*	0.2 ± 0.0^*
WBC count, × 10³/μL	6.7 ± 0.9	7.5 ± 0.7	6.2 ± 2.0
Platelet count, × 10³/μL	40 ± 10	1060 ± 130^*	950 ± 290^*

	*Conditional bcl-x^−/−*	Bled control	Unbled control
Spleen mass, g	5.2 ± 0.8	0.3 ± 0.0^*	0.1 ± 0.0^*
Hemoglobin level, g/dL	4.3 ± 0.5	6.5 ± 0.3^*	15.8 ± 1.3^*
Erythrocyte count, × 10⁶/μL	2.2 ± 0.2	4.1 ± 0.2^*	10.3 ± 0.5^*
MCHC, g/dL	32 ± 0.5	26 ± 0.2^*	33 ± 0.8
Reticulocyte count, × 10⁵/μL	1.5 ± 0.3	14 ± 1.0^*	2.7 ± 0.5^*
Total, %	6.8 ± 0.8	34 ± 1.9^*	2.6 ± 0.5^*
Early, %	55 ± 5	63 ± 3	10 ± 6^*
Middle, %	18 ± 3	21 ± 2	40 ± 2^*
Late, %	27 ± 3	16 ± 2^*	50 ± 7^*
MCV, fL	60 ± 1.2	58 ± 1.0	47 ± 2.0^*
Mature, fL	59 ± 1.4	48 ± 0.4^*	47 ± 1.5^*
Retic, fL	75 ± 1.2	76 ± 1.4	55 ± 1.9^*
RDW, %	20 ± 0.9	31 ± 0.2^*	12 ± 0.9^*
Mature, %	17 ± 0.9	15 ± 0.3^*	12 ± 0.2^*
Retic, %	15 ± 1.0	17 ± 0.2	11 ± 0.2^*
Bilirubin levels
Total, mg/dL	5.6 ± 1.3	0.2 ± 0.1^*	0.3 ± 0.1^*
Indirect, mg/dL	4.6 ± 1.0	0.1 ± 0.0^*	0.2 ± 0.0^*
WBC count, × 10³/μL	6.7 ± 0.9	7.5 ± 0.7	6.2 ± 2.0
Platelet count, × 10³/μL	40 ± 10	1060 ± 130^*	950 ± 290^*

Data are mean ± SEM of 16 mice, except for bilirubin levels (n = 6).

MCHC indicates mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; RDW, red blood cell distribution width; WBC, white blood cell.

P < .05 using t test comparing to conditional bcl-x^−/−.

View Large

This Feature Is Available To Subscribers Only