Characteristic immunophenotype of extranodal T/NK-cell neoplasms.
| Lymphoma Type . | T-cell Subset . | CD56 . | Cytotoxic Proteins . | CD30 . | EBV . | Cell Type . |
|---|---|---|---|---|---|---|
| Modified from Kinney MC, 19996; + = 50%-100%; +/- = 25%-49%; -/+ = 5%-24%; - = <5% | ||||||
| * most cases have a non-activated phenotype (TIA-1+, granzyme B-, perforin-). ** based on nodal cases | ||||||
| Abbreviations: SCPTCL, subcutaneous panniculitis-like T-cell lymphoma; ALCL, anaplastic large cell lymphoma; NT, not tested | ||||||
| Hepatosplenic | CD4-CD8->CD8+ | + | +* | -/+ | - | γδ>>αβ |
| SCPTCL | CD8+>CD4-CD8->CD4+ | -/+ | + | -/+ | - | αβ>γδ |
| ALCL, primary cutaneous | CD4+>CD4-CD8->CD8+ | -/+ | +/- | + | -** | αβ>γδ |
| Nasal/nasal type NK/T-cell | CD8+>CD4-CD8- | + | + | +/- | + | NK>γδ>αβ |
| Aggressive NK-cell leukemia | CD8+,CD4-CD8- | + | + | NT | -/+ | NK,T cell |
| Intestinal | CD4-CD8->CD8+>CD4+ | -/+ | + | +/- | αβ>γδ>>NK | |
| Blastic NK-cell lymphoma/leukemia | CD4 | + | + | NT | - | NK |
| Lymphoma Type . | T-cell Subset . | CD56 . | Cytotoxic Proteins . | CD30 . | EBV . | Cell Type . |
|---|---|---|---|---|---|---|
| Modified from Kinney MC, 19996; + = 50%-100%; +/- = 25%-49%; -/+ = 5%-24%; - = <5% | ||||||
| * most cases have a non-activated phenotype (TIA-1+, granzyme B-, perforin-). ** based on nodal cases | ||||||
| Abbreviations: SCPTCL, subcutaneous panniculitis-like T-cell lymphoma; ALCL, anaplastic large cell lymphoma; NT, not tested | ||||||
| Hepatosplenic | CD4-CD8->CD8+ | + | +* | -/+ | - | γδ>>αβ |
| SCPTCL | CD8+>CD4-CD8->CD4+ | -/+ | + | -/+ | - | αβ>γδ |
| ALCL, primary cutaneous | CD4+>CD4-CD8->CD8+ | -/+ | +/- | + | -** | αβ>γδ |
| Nasal/nasal type NK/T-cell | CD8+>CD4-CD8- | + | + | +/- | + | NK>γδ>αβ |
| Aggressive NK-cell leukemia | CD8+,CD4-CD8- | + | + | NT | -/+ | NK,T cell |
| Intestinal | CD4-CD8->CD8+>CD4+ | -/+ | + | +/- | αβ>γδ>>NK | |
| Blastic NK-cell lymphoma/leukemia | CD4 | + | + | NT | - | NK |