ALKgene dysregulation and the classification of anaplastic large cell lymphoma (ALCL).
| Abbreviations: SCV, small cell variant; EMA, epithelial membrane antigen; LyP, lymphomatoid papulosis; MF, mycosis fungoides; HD, Hodgkin's disease; HIV, human immunodeficiency virus |
| ALK-positive Group |
| Distinct clinicopathologic entity: |
| •young patients |
| •systemic disease |
| •variable histology (ALCL → SCV) |
| •T or null cell, EMA+ |
| ALK-negative Group |
| Heterogeneous group of lymphomas: |
| •primary cutaneous |
| •Hodgkin's related |
| •Secondary ALCL in patients with LyP, MF, HD |
| •CD30+ large B-cell lymphomas |
| •ALCL in HIV+ patients |
| Abbreviations: SCV, small cell variant; EMA, epithelial membrane antigen; LyP, lymphomatoid papulosis; MF, mycosis fungoides; HD, Hodgkin's disease; HIV, human immunodeficiency virus |
| ALK-positive Group |
| Distinct clinicopathologic entity: |
| •young patients |
| •systemic disease |
| •variable histology (ALCL → SCV) |
| •T or null cell, EMA+ |
| ALK-negative Group |
| Heterogeneous group of lymphomas: |
| •primary cutaneous |
| •Hodgkin's related |
| •Secondary ALCL in patients with LyP, MF, HD |
| •CD30+ large B-cell lymphomas |
| •ALCL in HIV+ patients |