Lymphoid neoplasms in the REAL/WHO classification.5,31
| **B and T/NK-cell neoplasms are grouped according to major clinical presentations (predominantly disseminated/leukemic, primary extranodal, predominantly nodal) |
| B-cell Neoplasms |
| Precursor B-cell neoplasm |
| • Precursor B-lymphoblastic leukemia/lymphoma (precursor B-cell acute lymphoblastic leukemia) |
| Mature (peripheral) B-cell neoplasms** |
| • Chronic lymphocytic leukemia/B-cell small lymphocytic lymphoma |
| • B-cell prolymphocytic leukemia |
| • Lymphoplasmacytic lymphoma |
| • Splenic marginal zone B-cell lymphoma (splenic lymphoma with villous lymphocytes) |
| • Hairy cell leukemia |
| • Plasma cell myeloma/Plasmacytoma |
| • Extranodal marginal zone B-cell lymphoma (MALT lymphoma) |
| • Nodal marginal zone B-cell lymphoma |
| • Follicular lymphoma |
| • Mantle cell lymphoma |
| • Diffuse large B-cell lymphomas |
| • Burkitt lymphoma/leukemia |
| T and NK-Cell Neoplasms |
| Precursor T-cell neoplasm |
| • Precursor T-lymphoblastic leukemia/lymphoma (precursor T-cell acute lymphoblastic leukemia) |
| • Blastoid NK-cell lymphoma |
| Mature (peripheral) T-cell neoplasms |
| • T-cell prolymphocytic leukemia |
| • T-cell large granular lymphocytic leukemia |
| • Aggressive NK-cell leukemia |
| • Adult T-cell lymphoma/leukemia (HTLV1+) |
| • Extranodal NK/T-cell lymphoma, nasal type |
| • Enteropathy-type T-cell lymphoma |
| • Hepatosplenic T-cell lymphoma |
| • Subcutaneous panniculitis-like T-cell lymphoma |
| • Mycosis fungoides/Sézary syndrome |
| • Primary cutaneous anaplastic large cell lymphoma |
| • Peripheral T-cell lymphoma, not otherwise specified |
| • Angioimmunoblastic T-cell lymphoma |
| • Primary systemic anaplastic large cell lymphoma |
| Hodgkin lymphoma (Hodgkin disease) |
| • Nodular lymphocyte predominant Hodgkin lymphoma |
| • Classical hodgkin lymphoma |
| Nodular sclerosis Hodgkin lymphoma (Grades 1 and 2) |
| Lymphocyte-rich classical Hodgkin lymphoma |
| Mixed cellularity Hodgkin lymphoma |
| Lymphocyte depleted Hodgkin lymphoma |
| **B and T/NK-cell neoplasms are grouped according to major clinical presentations (predominantly disseminated/leukemic, primary extranodal, predominantly nodal) |
| B-cell Neoplasms |
| Precursor B-cell neoplasm |
| • Precursor B-lymphoblastic leukemia/lymphoma (precursor B-cell acute lymphoblastic leukemia) |
| Mature (peripheral) B-cell neoplasms** |
| • Chronic lymphocytic leukemia/B-cell small lymphocytic lymphoma |
| • B-cell prolymphocytic leukemia |
| • Lymphoplasmacytic lymphoma |
| • Splenic marginal zone B-cell lymphoma (splenic lymphoma with villous lymphocytes) |
| • Hairy cell leukemia |
| • Plasma cell myeloma/Plasmacytoma |
| • Extranodal marginal zone B-cell lymphoma (MALT lymphoma) |
| • Nodal marginal zone B-cell lymphoma |
| • Follicular lymphoma |
| • Mantle cell lymphoma |
| • Diffuse large B-cell lymphomas |
| • Burkitt lymphoma/leukemia |
| T and NK-Cell Neoplasms |
| Precursor T-cell neoplasm |
| • Precursor T-lymphoblastic leukemia/lymphoma (precursor T-cell acute lymphoblastic leukemia) |
| • Blastoid NK-cell lymphoma |
| Mature (peripheral) T-cell neoplasms |
| • T-cell prolymphocytic leukemia |
| • T-cell large granular lymphocytic leukemia |
| • Aggressive NK-cell leukemia |
| • Adult T-cell lymphoma/leukemia (HTLV1+) |
| • Extranodal NK/T-cell lymphoma, nasal type |
| • Enteropathy-type T-cell lymphoma |
| • Hepatosplenic T-cell lymphoma |
| • Subcutaneous panniculitis-like T-cell lymphoma |
| • Mycosis fungoides/Sézary syndrome |
| • Primary cutaneous anaplastic large cell lymphoma |
| • Peripheral T-cell lymphoma, not otherwise specified |
| • Angioimmunoblastic T-cell lymphoma |
| • Primary systemic anaplastic large cell lymphoma |
| Hodgkin lymphoma (Hodgkin disease) |
| • Nodular lymphocyte predominant Hodgkin lymphoma |
| • Classical hodgkin lymphoma |
| Nodular sclerosis Hodgkin lymphoma (Grades 1 and 2) |
| Lymphocyte-rich classical Hodgkin lymphoma |
| Mixed cellularity Hodgkin lymphoma |
| Lymphocyte depleted Hodgkin lymphoma |