Immunophenotypic and genetic features of common T-cell neoplasms.
| Neoplasm . | CD3 (S;C) . | CD5 . | CD7 . | CD4 . | CD8 . | CD30 . | TCR . | NK16, 56 . | Cytotoxic granule . | EBV . | Genetic Abnormality . | T-Receptor Genes . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbreviations: R, rearranged; M, mutated; NK, natural killer cell; U, unmutated; O, ongoing mutations; TCR, T-cell receptor gene; Ig, immunoglobulin; NA, not available | ||||||||||||
| Key: + = >90% positive; +/− = > 50% positive; −/+ = < 50% positive; − = < 10% positive; Cytotoxic granule = TIA-1, perforin, and/or granzyme | ||||||||||||
| * Mutations in the Ig gene V region indicate exposure to antigen. | ||||||||||||
| T-prolymphocytic leukemia | + | − | +,+ | +/− | −/+ | − | αβ | − | − | − | inv 14 + 8 | R |
| T-large granular lymphoproliferative disease | + | − | +,+ | − | + | − | αβ | +,− | + | − | none known | R |
| NK large granlular lymphoproliferative disease | − | − | +, − | − | +/− | − | − | −,+ | + | + | none known | G |
| Extranodal NK/T-cell lymphoma | −;+ | − | −/+ | − | − | − | − | NA,+ | + | ++ | none known | G |
| Hepatosplenic T-cell lymphoma | + | − | + | − | − | − | γδ>>αβ | +,−/+ | + | − | i(7q)(q10) | R |
| Enteropathy-type T-cell lymphoma | + | + | + | − | +/− | +/− | αβ>>γδ | − | + | − | none known | R |
| Mycosis fungoides | + | + | −/+ | + | − | − | αβ | − | − | − | None known | R |
| Cutaneous anaplastic large cell lymphoma | + | +/− | +/− | +/− | − | ++ | αβ | − | −/+ | − | none known | R |
| Subcutaneous panniculitis-like T-cell | + | + | + | − | + | −/+ | αβ>γδ | −,+/− | + | − | none known | R |
| Peripheral T-cell lymphoma, unspecified | +/− | +/− | +/− | +/− | −/+ | −/+ | αβ>γδ | −/+ | −/+ | −/+ | inv 14; +8, complex | R |
| Angioimmunoblastic | + | + | + | +/− | −/+ | − | αβ | − | NA | +/− | +3 +5 +X | R |
| Primary systemic anaplastic large cell lymphoma | +/− | +/− | NA | −/+ | −/+ | ++ | αβ | − | + | − | t(2;5); NPM/ALK | R |
| Neoplasm . | CD3 (S;C) . | CD5 . | CD7 . | CD4 . | CD8 . | CD30 . | TCR . | NK16, 56 . | Cytotoxic granule . | EBV . | Genetic Abnormality . | T-Receptor Genes . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbreviations: R, rearranged; M, mutated; NK, natural killer cell; U, unmutated; O, ongoing mutations; TCR, T-cell receptor gene; Ig, immunoglobulin; NA, not available | ||||||||||||
| Key: + = >90% positive; +/− = > 50% positive; −/+ = < 50% positive; − = < 10% positive; Cytotoxic granule = TIA-1, perforin, and/or granzyme | ||||||||||||
| * Mutations in the Ig gene V region indicate exposure to antigen. | ||||||||||||
| T-prolymphocytic leukemia | + | − | +,+ | +/− | −/+ | − | αβ | − | − | − | inv 14 + 8 | R |
| T-large granular lymphoproliferative disease | + | − | +,+ | − | + | − | αβ | +,− | + | − | none known | R |
| NK large granlular lymphoproliferative disease | − | − | +, − | − | +/− | − | − | −,+ | + | + | none known | G |
| Extranodal NK/T-cell lymphoma | −;+ | − | −/+ | − | − | − | − | NA,+ | + | ++ | none known | G |
| Hepatosplenic T-cell lymphoma | + | − | + | − | − | − | γδ>>αβ | +,−/+ | + | − | i(7q)(q10) | R |
| Enteropathy-type T-cell lymphoma | + | + | + | − | +/− | +/− | αβ>>γδ | − | + | − | none known | R |
| Mycosis fungoides | + | + | −/+ | + | − | − | αβ | − | − | − | None known | R |
| Cutaneous anaplastic large cell lymphoma | + | +/− | +/− | +/− | − | ++ | αβ | − | −/+ | − | none known | R |
| Subcutaneous panniculitis-like T-cell | + | + | + | − | + | −/+ | αβ>γδ | −,+/− | + | − | none known | R |
| Peripheral T-cell lymphoma, unspecified | +/− | +/− | +/− | +/− | −/+ | −/+ | αβ>γδ | −/+ | −/+ | −/+ | inv 14; +8, complex | R |
| Angioimmunoblastic | + | + | + | +/− | −/+ | − | αβ | − | NA | +/− | +3 +5 +X | R |
| Primary systemic anaplastic large cell lymphoma | +/− | +/− | NA | −/+ | −/+ | ++ | αβ | − | + | − | t(2;5); NPM/ALK | R |