Results of analyses of risk of first stroke in homozygous sickle cell disease (SS) patients: Data from the Cooperative Study of Sickle Cell Disease (CSSCD).
| A. Infarctive Stroke . | . | . | . |
|---|---|---|---|
| Final multivariate model: Five predictors significant at p < 0.05 . | . | ||
| Predictor . | Relative Risk . | 95% CI . | p value . |
| Prior transient ischemic attack (TIA) | 56.0 | (12.0, 285) | < 0.001 |
| Baseline Hb (g/dL) decrease | 1.85 per 1 g/dL | (1.32, 2.59) | < 0.001 |
| Acute chest syndrome within previous two weeks | 7.03 | (1.85, 26.7) | 0.001 |
| Acute chest syndrome rate | 2.39 per event /yr | (1.27, 4.48) | 0.005 |
| Systolic blood pressure rise | 1.31 per 10 mm Hg | (1.03, 1.67) | 0.033 |
| A. Infarctive Stroke . | . | . | . |
|---|---|---|---|
| Final multivariate model: Five predictors significant at p < 0.05 . | . | ||
| Predictor . | Relative Risk . | 95% CI . | p value . |
| Prior transient ischemic attack (TIA) | 56.0 | (12.0, 285) | < 0.001 |
| Baseline Hb (g/dL) decrease | 1.85 per 1 g/dL | (1.32, 2.59) | < 0.001 |
| Acute chest syndrome within previous two weeks | 7.03 | (1.85, 26.7) | 0.001 |
| Acute chest syndrome rate | 2.39 per event /yr | (1.27, 4.48) | 0.005 |
| Systolic blood pressure rise | 1.31 per 10 mm Hg | (1.03, 1.67) | 0.033 |
| B. Hemorrhagic Stroke . | . | . | . |
|---|---|---|---|
| Final multivariate model: Two predictors significant at p < 0.05 . | . | ||
| Predictor . | Relative Risk . | 95% CI . | p value . |
| Abbreviations: CI, confidence interval Source: Ohene-Frempong et al. Blood. 1998;91:288-294 | |||
| Baseline Hb (g/dL) decrease | 1.61 per 1 g/dL | (1.11, 2.35) | 0.013 |
| WBC (1x109/L) increase | 1.94 per 5x109/L | (1.73, 2.18) | 0.026 |
| B. Hemorrhagic Stroke . | . | . | . |
|---|---|---|---|
| Final multivariate model: Two predictors significant at p < 0.05 . | . | ||
| Predictor . | Relative Risk . | 95% CI . | p value . |
| Abbreviations: CI, confidence interval Source: Ohene-Frempong et al. Blood. 1998;91:288-294 | |||
| Baseline Hb (g/dL) decrease | 1.61 per 1 g/dL | (1.11, 2.35) | 0.013 |
| WBC (1x109/L) increase | 1.94 per 5x109/L | (1.73, 2.18) | 0.026 |