Summary of Amphotericin B (AmB) formulations.
| . | AmB . | L-AmB . | ABLC . | ABCD . |
|---|---|---|---|---|
| Abbreviations: HPC, hydrogenated phosphatidylcholine; CHOL, cholesterol; DMPC, dimyristoyl phosphatidylcholine; DMPG, dimyristoyl phosphatidylglycerol | ||||
| Trade Name (US) | Fungizone | AmBisome | Abelcet | Amphotec |
| Lipid components | Deoxycholate | HPC/CHOL/DSPG | DMPC/DMPG | Cholesterylsulfate |
| Mol % AmB | 34% | 10% | 35 % | 50% |
| Standard dose | 0.5 – 1.5 mg/kg | 3-5 mg/kg | 3-5 mg/kg | 3-5 mg/kg |
| Relative nephrotoxicity | ++++ | + | ++ | ++ |
| Infusion related toxicity | +++ | + | ++ | ++ |
| . | AmB . | L-AmB . | ABLC . | ABCD . |
|---|---|---|---|---|
| Abbreviations: HPC, hydrogenated phosphatidylcholine; CHOL, cholesterol; DMPC, dimyristoyl phosphatidylcholine; DMPG, dimyristoyl phosphatidylglycerol | ||||
| Trade Name (US) | Fungizone | AmBisome | Abelcet | Amphotec |
| Lipid components | Deoxycholate | HPC/CHOL/DSPG | DMPC/DMPG | Cholesterylsulfate |
| Mol % AmB | 34% | 10% | 35 % | 50% |
| Standard dose | 0.5 – 1.5 mg/kg | 3-5 mg/kg | 3-5 mg/kg | 3-5 mg/kg |
| Relative nephrotoxicity | ++++ | + | ++ | ++ |
| Infusion related toxicity | +++ | + | ++ | ++ |