Components contributing to posttransplant malignancies.
| Abbreviations: HSC, hemopoietic stem cells; GVHD, graft-versus-host disease; EBV, Epstein Barr virus; HPV, human papilloma virus. |
| Milieu |
| – pre-existing |
| – genetic predisposition |
| – chromosomal instability |
| – mutation |
| –pretransplant therapy |
| – transplant related |
| – chemotherapy |
| – irradiation |
| – antibodies |
| Source of HSC |
| – syngeneic |
| – allogeneic |
| – chronic stimulation |
| – autologous |
| – pre-exposed to therapy |
| Immunoincompetence |
| – slow immune reconstitution |
| – GVHD |
| – prophylaxis |
| – therapy |
| Infections |
| – viral |
| – EBV |
| – HPV |
| – other? |
| – bacterial |
| Chronic disease |
| – chronic GVHD |
| – inflammation |
| – immunosuppressive therapy |
| – defective repair |
| – hormonal imbalance |
| – nutritional deficiencies |
| Social habits |
| – smoking |
| – other? |
| Abbreviations: HSC, hemopoietic stem cells; GVHD, graft-versus-host disease; EBV, Epstein Barr virus; HPV, human papilloma virus. |
| Milieu |
| – pre-existing |
| – genetic predisposition |
| – chromosomal instability |
| – mutation |
| –pretransplant therapy |
| – transplant related |
| – chemotherapy |
| – irradiation |
| – antibodies |
| Source of HSC |
| – syngeneic |
| – allogeneic |
| – chronic stimulation |
| – autologous |
| – pre-exposed to therapy |
| Immunoincompetence |
| – slow immune reconstitution |
| – GVHD |
| – prophylaxis |
| – therapy |
| Infections |
| – viral |
| – EBV |
| – HPV |
| – other? |
| – bacterial |
| Chronic disease |
| – chronic GVHD |
| – inflammation |
| – immunosuppressive therapy |
| – defective repair |
| – hormonal imbalance |
| – nutritional deficiencies |
| Social habits |
| – smoking |
| – other? |