Donor cell contribution to nonhematopoietic tissues after whole bone marrow or stem cell transplantation in the mouse.
| Cells Transplanted . | Target Tissue . | Injury Induced . | Approximate Frequency . | Ref. . |
|---|---|---|---|---|
| Abbreviations: WBM; TBI, total body irradiation; KTSL; SP; FAH, fumaryl acetoacetate hydrolase; HSC, hematopoietic stem cells | ||||
| WBM | Macro- and microglia | TBI | 0.5–2% | 49 |
| WBM | Skeletal muscle | TBI + intra-muscular cardiotoxin injury | Minimal | 39 |
| WBM | Skeletal, cardiac muscle | TBI | Not given | 50 |
| WBM | Skeletal muscle | Exercise | 3.5% | 51 |
| WBM | Endothelial cells | TBI | Not given | 52 |
| WBM | Neurons | TBI | 0.2–0.3% | 53 |
| WBM | Neurons | TBI | 0.3–2.3% | 54 |
| WBM | Neurons | TBI and contusion | 0 | 55 |
| WBM | Hepatocytes | TBI | 2.2% | 56 |
| SP | Skeletal Muscle | TBI + genetic deficiency (mdx mouse) | 1–10 | 40 |
| KTSL | Liver | TBI + genetic deficiency (FAH) | Rare | 57 |
| Lin− Kit-hi | Heart/vasculature | Coronary artery ligation | 54% of new tissue | 58 |
| CD34+ | Vasculature | Coronary artery ligation | 20–25 | 59 |
| SP | Cardiac muscle, endothelial cells | TBI + coronary artery ligation | 0.02 2–4 | 60 |
| “Homed” HSC | Lung alveoli | TBI | 20 | 61 |
| Lung bronchi | TBI | 3.7 | ||
| Esophagus | TBI | 1.81 | ||
| Stomach | TBI | 0.52 | ||
| Small bowel | TBI | 0.87 | ||
| Large bowel | TBI | 0.19 | ||
| Bile duct | TBI | 0.84 | ||
| Skin | TBI | 3.39 | ||
| Single KTSL | Multiple | None | 0 | 62 |
| Cells Transplanted . | Target Tissue . | Injury Induced . | Approximate Frequency . | Ref. . |
|---|---|---|---|---|
| Abbreviations: WBM; TBI, total body irradiation; KTSL; SP; FAH, fumaryl acetoacetate hydrolase; HSC, hematopoietic stem cells | ||||
| WBM | Macro- and microglia | TBI | 0.5–2% | 49 |
| WBM | Skeletal muscle | TBI + intra-muscular cardiotoxin injury | Minimal | 39 |
| WBM | Skeletal, cardiac muscle | TBI | Not given | 50 |
| WBM | Skeletal muscle | Exercise | 3.5% | 51 |
| WBM | Endothelial cells | TBI | Not given | 52 |
| WBM | Neurons | TBI | 0.2–0.3% | 53 |
| WBM | Neurons | TBI | 0.3–2.3% | 54 |
| WBM | Neurons | TBI and contusion | 0 | 55 |
| WBM | Hepatocytes | TBI | 2.2% | 56 |
| SP | Skeletal Muscle | TBI + genetic deficiency (mdx mouse) | 1–10 | 40 |
| KTSL | Liver | TBI + genetic deficiency (FAH) | Rare | 57 |
| Lin− Kit-hi | Heart/vasculature | Coronary artery ligation | 54% of new tissue | 58 |
| CD34+ | Vasculature | Coronary artery ligation | 20–25 | 59 |
| SP | Cardiac muscle, endothelial cells | TBI + coronary artery ligation | 0.02 2–4 | 60 |
| “Homed” HSC | Lung alveoli | TBI | 20 | 61 |
| Lung bronchi | TBI | 3.7 | ||
| Esophagus | TBI | 1.81 | ||
| Stomach | TBI | 0.52 | ||
| Small bowel | TBI | 0.87 | ||
| Large bowel | TBI | 0.19 | ||
| Bile duct | TBI | 0.84 | ||
| Skin | TBI | 3.39 | ||
| Single KTSL | Multiple | None | 0 | 62 |