Classification of well-characterized antigens driving donor T-cell responses.
| Abbreviations: CMV, cytomegalovirus; EBNA, Epstein Barr nuclear antigen; EBV, Epstein Barr virus; HA, minor histocompatibility antigen; HB-1, B cell minor histocompatibility antigen-1; IE1, intermediate-early 1 antigen; LMP, latent membrane protein; pp,65 phosphoprotein 65 antigen; t, translocation; WT1, Wilms tumor 1 . |
| Non-tissue-restricted |
| Minor histocompatibility antigens |
| Major histocompatibility antigens directly and indirectly presented |
| Tissue-restricted/aberrantly expressed |
| Minor histocompatibility antigens: HA-1, HA-2, HB-1 |
| Nonalleleic: proteinase 3, WT-1, telomerase |
| Malignant-cell-restricted |
| Products of chromosome translocation: t9:22, t15:17 |
| Virus-specific |
| CMV: pp65, IE1 |
| EBV: EBNA 1-3, LMP-1, LMP-2 |
| Abbreviations: CMV, cytomegalovirus; EBNA, Epstein Barr nuclear antigen; EBV, Epstein Barr virus; HA, minor histocompatibility antigen; HB-1, B cell minor histocompatibility antigen-1; IE1, intermediate-early 1 antigen; LMP, latent membrane protein; pp,65 phosphoprotein 65 antigen; t, translocation; WT1, Wilms tumor 1 . |
| Non-tissue-restricted |
| Minor histocompatibility antigens |
| Major histocompatibility antigens directly and indirectly presented |
| Tissue-restricted/aberrantly expressed |
| Minor histocompatibility antigens: HA-1, HA-2, HB-1 |
| Nonalleleic: proteinase 3, WT-1, telomerase |
| Malignant-cell-restricted |
| Products of chromosome translocation: t9:22, t15:17 |
| Virus-specific |
| CMV: pp65, IE1 |
| EBV: EBNA 1-3, LMP-1, LMP-2 |