Non-HLA genes associated with risk of infections and transplant-related mortality.
| Gene . | Alleles . | Effect . | R or D genotype . | Reference . |
|---|---|---|---|---|
| Abbreviations: MPO, myeloperoxidase, an enzyme found primarily in the lysomes of neutrophils. A single base substitution (G > A) in the promoter region of the MPO gene (−463) decreases expression and alters binding site for the transcription factor; FcγRIIa, Fcγ receptor, polymorphisms of the receptor affect receptor affinity and specificity; FcγRIIIb, Fcγ receptor HNA1a and HNA1b, isoforms affect different ligand binding of antibodies; MBL, mannose-binding lectin. | ||||
| MPO | AG/AA D | Increased bacterial infection. Increased risk of leukemic death | D | Rocha et al18 |
| FcγRIIa | R-131 | Increased first overall infections | R | Rocha et al18 |
| FcγRIIIb | HNA1a/HNA1a | Delayed neutrophil recovery Severe infection Increased risk of leukemic death | D | Rocha et al18 |
| HNA1b/HNA1b | Increased transplantation-related mortality rates | |||
| HNA1a/HNA1b | Quick neutrophil recovery | D | ||
| MBL | HYA haplotype | Decreased infection | D/R | Mullighan et al55 |
| MBL2 | Increased risk of major infection | D/R | ||
| Gene . | Alleles . | Effect . | R or D genotype . | Reference . |
|---|---|---|---|---|
| Abbreviations: MPO, myeloperoxidase, an enzyme found primarily in the lysomes of neutrophils. A single base substitution (G > A) in the promoter region of the MPO gene (−463) decreases expression and alters binding site for the transcription factor; FcγRIIa, Fcγ receptor, polymorphisms of the receptor affect receptor affinity and specificity; FcγRIIIb, Fcγ receptor HNA1a and HNA1b, isoforms affect different ligand binding of antibodies; MBL, mannose-binding lectin. | ||||
| MPO | AG/AA D | Increased bacterial infection. Increased risk of leukemic death | D | Rocha et al18 |
| FcγRIIa | R-131 | Increased first overall infections | R | Rocha et al18 |
| FcγRIIIb | HNA1a/HNA1a | Delayed neutrophil recovery Severe infection Increased risk of leukemic death | D | Rocha et al18 |
| HNA1b/HNA1b | Increased transplantation-related mortality rates | |||
| HNA1a/HNA1b | Quick neutrophil recovery | D | ||
| MBL | HYA haplotype | Decreased infection | D/R | Mullighan et al55 |
| MBL2 | Increased risk of major infection | D/R | ||