Table 7.

Sapporo investigational criteria for diagnosis of antiphospholipid (aPL) syndrome.

Abbreviations: aCL, anticardiolipin; aPL, antiphospholipid; β2GPI, β2-glycoprotein I; ELISA, enzyme-linked immunosorbent assay; LA, lupus anticoagulant. 
Clinical 

  • Vascular thromboses (one or more episodes of arterial, venous, or small vessel thrombosis)

  • Pregnancy morbidity

 
Laboratory 

  • aCL IgG and/or IgM antibody present in medium or high titer on 2 or more occasions, at least 6 weeks apart, measured by a standard ELISA for β2GPI-dependent aCL antibodies

  • LA in plasma, on 2 or more occasions, at least 6 weeks apart

 
Definite aPL syndrome is considered to be present if at least one of the clinical criteria and one of the laboratory criteria are met. 
Abbreviations: aCL, anticardiolipin; aPL, antiphospholipid; β2GPI, β2-glycoprotein I; ELISA, enzyme-linked immunosorbent assay; LA, lupus anticoagulant. 
Clinical 

  • Vascular thromboses (one or more episodes of arterial, venous, or small vessel thrombosis)

  • Pregnancy morbidity

 
Laboratory 

  • aCL IgG and/or IgM antibody present in medium or high titer on 2 or more occasions, at least 6 weeks apart, measured by a standard ELISA for β2GPI-dependent aCL antibodies

  • LA in plasma, on 2 or more occasions, at least 6 weeks apart

 
Definite aPL syndrome is considered to be present if at least one of the clinical criteria and one of the laboratory criteria are met. 
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