Table 4.

Recent results with unrelated grafts.

GVHD
ReferenceYear of ReportYear of TransplantNo. of PtsAge, Yrs Median (range)ConditioningGVHD PreventionGraft Failure %AcuteChronicSurvival %
Abbreviations: NMDP, National Marrow Donor Program; IBMTR, International Bone Marrow Transplant Registry; JMDP, Japanese Marrow Donor Program; CY, cyclophosphamide; TBI, total body irradiation; LNI, lymph node irradiation; ATG, antithymocyte globulin; MTX, methotrexate; CSP, cyclosporine 
NMDP39  1999 1988–95 141 17 (0.9–47) CY/TBI MTX/CSP 11% 52 31 36% 
     CY/LNI CSP, others     
     CY/ATG      
IBMTR30  2000 1991–97 298 0–40 — — — — — 44% ≤ 20 yrs 35% 21–40 yrs 
NMDP40  2001 1994–99 50 14 (1.3–46) CY/ATG/2-6 Gy TBI MTX/CSP 2% 61 37 58 
JMDP41  2002 1993–2000 154 17 (1–46) CY/ATG/TBI or LNI MTX/CSP FK506 11% 29 30 56 
GVHD
ReferenceYear of ReportYear of TransplantNo. of PtsAge, Yrs Median (range)ConditioningGVHD PreventionGraft Failure %AcuteChronicSurvival %
Abbreviations: NMDP, National Marrow Donor Program; IBMTR, International Bone Marrow Transplant Registry; JMDP, Japanese Marrow Donor Program; CY, cyclophosphamide; TBI, total body irradiation; LNI, lymph node irradiation; ATG, antithymocyte globulin; MTX, methotrexate; CSP, cyclosporine 
NMDP39  1999 1988–95 141 17 (0.9–47) CY/TBI MTX/CSP 11% 52 31 36% 
     CY/LNI CSP, others     
     CY/ATG      
IBMTR30  2000 1991–97 298 0–40 — — — — — 44% ≤ 20 yrs 35% 21–40 yrs 
NMDP40  2001 1994–99 50 14 (1.3–46) CY/ATG/2-6 Gy TBI MTX/CSP 2% 61 37 58 
JMDP41  2002 1993–2000 154 17 (1–46) CY/ATG/TBI or LNI MTX/CSP FK506 11% 29 30 56 
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