Frequently-used disease assessment tools for clinical trials of autoimmune diseases.
| Disease . | Assessments of Disease Activity . |
|---|---|
| Systemic sclerosis (SSc) | Modified Rodnan Skin Score (mRSS): skin thickness assessed by palpation: score = 0–51 Modified health assessment questionnaire—disability index (m-HAQ-DI): functional index based on questionnaire about daily activities with scale of 0–3. |
| Systemic lupus erythematosus (SLE) | Systemic Lupus Erythematosus disease activity index (SLEDAI) British Isles Lupus Activity Group scale (BILAG): 8 system evaluation with each system graded A (active disease) to E (system never involved) |
| Rheumatoid arthritis (RA) | American College of Rheumatology (ACR) score e.g., ACR 20%, ACR-50%, ACR 70%. Composite score including A. (1) swollen joint count and (2) tender joint count combined with B: (1) Physician assessment scale—visual analogue scale, (2) Patients global assessment—visual analogue scale, (3) Pain—visual analogue scale, (4) Patients self-assess disability, (5) acute phase reactant (ESR or CRP). Example: ACR20 requires 20% or greater improvement in A(1) and A(2) together with 20% or greater improvement in 3 of 5 B parameters. |
| Juvenile idiopathic arthritis (JIA) | Physician’s global assessment—visual analogue scale (0–3) Parent/child assessment of well-being—child health assessment questionnaire (CHAQ—scale of 0–3) Functional ability child health assessment questionnaire (CHAQ—scale of 0–3) Number of joints with arthritis (active joint count) Number of joints with limited range of motion (EPM-ROM) Erythrocyte sedimentation rate |
| Multiple sclerosis (MS) | Extended Disability Status Scale (EDSS) Scripps Neurological Rating Scale (SNRS) |
| Disease . | Assessments of Disease Activity . |
|---|---|
| Systemic sclerosis (SSc) | Modified Rodnan Skin Score (mRSS): skin thickness assessed by palpation: score = 0–51 Modified health assessment questionnaire—disability index (m-HAQ-DI): functional index based on questionnaire about daily activities with scale of 0–3. |
| Systemic lupus erythematosus (SLE) | Systemic Lupus Erythematosus disease activity index (SLEDAI) British Isles Lupus Activity Group scale (BILAG): 8 system evaluation with each system graded A (active disease) to E (system never involved) |
| Rheumatoid arthritis (RA) | American College of Rheumatology (ACR) score e.g., ACR 20%, ACR-50%, ACR 70%. Composite score including A. (1) swollen joint count and (2) tender joint count combined with B: (1) Physician assessment scale—visual analogue scale, (2) Patients global assessment—visual analogue scale, (3) Pain—visual analogue scale, (4) Patients self-assess disability, (5) acute phase reactant (ESR or CRP). Example: ACR20 requires 20% or greater improvement in A(1) and A(2) together with 20% or greater improvement in 3 of 5 B parameters. |
| Juvenile idiopathic arthritis (JIA) | Physician’s global assessment—visual analogue scale (0–3) Parent/child assessment of well-being—child health assessment questionnaire (CHAQ—scale of 0–3) Functional ability child health assessment questionnaire (CHAQ—scale of 0–3) Number of joints with arthritis (active joint count) Number of joints with limited range of motion (EPM-ROM) Erythrocyte sedimentation rate |
| Multiple sclerosis (MS) | Extended Disability Status Scale (EDSS) Scripps Neurological Rating Scale (SNRS) |