Recurrent genetic subtypes of B- and T-cell acute lymphoblastic leukemia (ALL).
| Subtype . | Associated Genetic Abnormalities . | Frequency in Children . | Risk Category . |
|---|---|---|---|
| B-precursor ALL | Hyperdiploid DNA content; trisomies of chromosomes 4, 10, 17 | 25% of B precursor cases | Low |
| t(12;21)(p13;q22): | 28% of B precursor cases | Low | |
| TEL/AML1 11q23/ rearrangements; | 4% of B precursor cases; | High | |
| particularly t(4;11)(q21;q23) | < 80% of infant ALL | ||
| t(1;19)9q23;p13) – E2A/PBX1 | 6% of B precursor cases | High | |
| t(9;22)(q34;q11): BCR/ABL | 2% of B precursor cases | Very high | |
| Hypodiploidy | Relatively rare | Very high | |
| B-ALL | t(8;14)(q24;q32) – IgH/MYC | 5% of all B lineage ALL cases | High |
| T-ALL | Numerous translocations involving the TCR αβ (7q35) or TCR γδ (14q11) loci | 7% of ALL cases | Not clearly defined |
| Subtype . | Associated Genetic Abnormalities . | Frequency in Children . | Risk Category . |
|---|---|---|---|
| B-precursor ALL | Hyperdiploid DNA content; trisomies of chromosomes 4, 10, 17 | 25% of B precursor cases | Low |
| t(12;21)(p13;q22): | 28% of B precursor cases | Low | |
| TEL/AML1 11q23/ rearrangements; | 4% of B precursor cases; | High | |
| particularly t(4;11)(q21;q23) | < 80% of infant ALL | ||
| t(1;19)9q23;p13) – E2A/PBX1 | 6% of B precursor cases | High | |
| t(9;22)(q34;q11): BCR/ABL | 2% of B precursor cases | Very high | |
| Hypodiploidy | Relatively rare | Very high | |
| B-ALL | t(8;14)(q24;q32) – IgH/MYC | 5% of all B lineage ALL cases | High |
| T-ALL | Numerous translocations involving the TCR αβ (7q35) or TCR γδ (14q11) loci | 7% of ALL cases | Not clearly defined |