Table 9. Important drug interactions... | American Society of Hematology

Table 9.

Important drug interactions with azoles: effect of other agents on azoles.

		Pharmacokinetics of Other Drugs Affecting Azoles
Effect of Other Agents on Azoles	Azole Used	Effect on Azole	Adjust Dose of Azole or Avoid Concomitant Drug	Monitoring
Abbreviations: AUC, area under the curve
Rifabutin, rifabutin	Itraconazole	↓↓ AUC	Avoid rifampin/rifabutin in patients receiving triazoles	Monitor azole level
	Voriconazole	↓↓↓ AUC
	Fluconazole	↓ AUC
Phenytoin	Itraconazole	↓↓↓↓ AUC	Avoid concomitant use
	Voriconazole	↓ AUC	Double voriconazole dose
H2-blockers	Itraconazole	↓ AUC 30–50%	Use with cola, increase dose
Proton pump inhibitors	capsule	↓ AUC 64%
Anti-retroviral agents
Didanosine	Itraconazole	↓ AUC	Adjust azole dose according to azole level	Monitor azole level
Nevirapine	Voriconazole	↓? AUC
Delavirdine		↑? AUC
Phenobarbital	Itraconazole	↓↓↓↓ AUC	Avoid concomitant use	Monitor azole level
Carbamazepine	Itraconazole
	Voriconazole
Isoniazid	Itraconazole

		Pharmacokinetics of Other Drugs Affecting Azoles
Effect of Other Agents on Azoles	Azole Used	Effect on Azole	Adjust Dose of Azole or Avoid Concomitant Drug	Monitoring
Abbreviations: AUC, area under the curve
Rifabutin, rifabutin	Itraconazole	↓↓ AUC	Avoid rifampin/rifabutin in patients receiving triazoles	Monitor azole level
	Voriconazole	↓↓↓ AUC
	Fluconazole	↓ AUC
Phenytoin	Itraconazole	↓↓↓↓ AUC	Avoid concomitant use
	Voriconazole	↓ AUC	Double voriconazole dose
H2-blockers	Itraconazole	↓ AUC 30–50%	Use with cola, increase dose
Proton pump inhibitors	capsule	↓ AUC 64%
Anti-retroviral agents
Didanosine	Itraconazole	↓ AUC	Adjust azole dose according to azole level	Monitor azole level
Nevirapine	Voriconazole	↓? AUC
Delavirdine		↑? AUC
Phenobarbital	Itraconazole	↓↓↓↓ AUC	Avoid concomitant use	Monitor azole level
Carbamazepine	Itraconazole
	Voriconazole
Isoniazid	Itraconazole